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Purinergic receptor: Wikis


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Purinergic receptors, also known as purinoceptors, are a family of newly characterized plasma membrane molecules involved in several and as yet only partially known cellular functions such as vascular reactivity, apoptosis and cytokine secretion.

Little is known about the effect extracellular microenvironment has on their function.

Fibroblasts share several features with smooth muscle cells and are an important constituent of the atherosclerotic plaque.

These receptors have their effect of high glucose concentration on ATP-mediated responses in human fibroblasts.

The members of the family include the following:

Name Activation Class
P1 receptors adenosine G protein-coupled receptors
P2Y receptors nucleotides G protein-coupled receptors
P2X receptors ATP ligand-gated ion channel


Inhibitors of purinergic receptors include clopidogrel, prasugrel and ticlopidine, as well as the investigational drug ticagrelor. All of these are antiplatelet agents that block P2Y12 receptors.

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