| Purpura fulminans | |
|---|---|
| Classification and external resources | |
| ICD-10 | D65. (ILDS D65.x20) |
| ICD-9 | 286.6 |
| DiseasesDB | 34463 |
| MeSH | D011695 |
Purpura fulminans (also known as "Purpura gangrenosa"[1]:825) is a haemorrhagic condition usually associated with sepsis or previous infection. It occurs mainly in babies and small children.
It was first described by Guelliot in 1884.[2]
Contents |
It is a life-threatening disorder of acute onset. It is characterized by cutaneous haemorrhage and necrosis (tissue death), low blood pressure, fever and disseminated intravascular coagulation.{{Fact|date=April 2009}
Common causes are severe infection (especially with meningococcus and Gram-negative organisms),[3] and deficiency of the natural anticoagulants protein C or protein S in the blood.[4] In some cases, a cause is never found.[3]
Treatment is mainly by removing the underlying cause and with supportive treatment. In many cases, digits may need to be amputated when their blood supply has ceased completely.[3]
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