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Pyrazole
Pyrazole numbering.png
Pyrazole3d.png
IUPAC name
Other names 1,2-diazole
Identifiers
CAS number 288-13-1 Yes check.svgY
SMILES
ChemSpider ID 1019
Properties
Molecular formula C3H4N2
Molar mass 68.07 g/mol
Melting point

66-70 °C

Boiling point

168-188 °C

 Yes check.svgY (what is this?)  (verify)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pyrazole refers both to the class of simple aromatic ring organic compounds of the heterocyclic series characterized by a 5-membered ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions, and to the unsubstituted parent compound. Being so composed and having pharmacological effects on humans, they are classified as alkaloids, although they are rare in nature.

Pyrazoles

Pyrazoles are produced synthetically through the reaction of α,β-unsaturated aldehydes with hydrazine and subsequent dehydrogenation.

Pyrazoles synthesis.png

In medicine, pyrazoles are used for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.

Pyrazoles react with potassium borohydride to form a class of ligands known as Scorpionates.

Structurally related compounds are pyrazoline and pyrazolidine.

Pyrazole derivatives.png

See also

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