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Quinupramine
Systematic (IUPAC) name
(RS)-11-quinuclidin-3-yl-5,6-dihydrobenzo[b][1]benzazepine
Identifiers
CAS number 31721-17-2
ATC code  ?
PubChem 93154
ChemSpider 84098
Chemical data
Formula C21H24N2
Mol. mass 304.43 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Quinupramine (Kevopril, Kinupril, Adeprim, Quinuprine) is a tricyclic antidepressant (TCA) used in Europe for the treatment of depression. [1] [2]

Pharmacologically, quinupramine acts in vitro as a strong muscarinic acetylcholine receptor antagonist (anticholinergic) and H1 receptor antagonist (antihistamine), moderate 5-HT2 receptor antagonist, and weak serotonin and norepinephrine reuptake inhibitor.[3] It has negligible affinity for the α1-adrenergic, α2-adrenergic, β-adrenergic, and D2 receptors.[3]

Clinically, quinupramine is reported to be stimulating similarly to imipramine, desipramine, and demexiptiline. [4] It can be inferred that its metabolites may have stronger effects on the reuptake of norepinephrine than quinupramine itself.

See also

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