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RAR-related orphan receptor beta: Wikis


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RAR-related orphan receptor B

PDB rendering based on 1k4w.
Available structures
1k4w, 1n4h, 1nq7
Symbols RORB; NR1F2; ROR-BETA; RZRB; bA133M9.1
External IDs OMIM601972 MGI1343464 HomoloGene38250 GeneCards: RORB Gene
RNA expression pattern
PBB GE RORB 206443 at tn.png
More reference expression data
Species Human Mouse
Entrez 6096 225998
Ensembl ENSG00000198963 ENSMUSG00000036192
UniProt Q92753 Q8R1B8
RefSeq (mRNA) NM_006914 NM_001043354
RefSeq (protein) NP_008845 NP_001036819
Location (UCSC) Chr 9:
76.3 - 76.49 Mb
Chr 19:
19 - 19.06 Mb
PubMed search [1] [2]

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor encoded by the RORB gene.

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.[1]



RAR-related orphan receptor beta has been shown to interact with NME1.[2]

See also


  1. ^ "Entrez Gene: RORB RAR-related orphan receptor B".  
  2. ^ Paravicini, G; Steinmayr M, André E, Becker-André M (Oct. 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. (UNITED STATES) 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. ISSN 0006-291X. PMID 8858107.  

Further reading

  • Beeson WM, Perry TW, Zurcher TD (1977). "Effect of supplemental zinc on growth and on hair and blood serum levels of beef cattle.". J. Anim. Sci. 45 (1): 160–5. PMID 885817.  
  • Giguère V, Tini M, Flock G, et al. (1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.". Genes Dev. 8 (5): 538–53. doi:10.1101/gad.8.5.538. PMID 7926749.  
  • Carlberg C, Hooft van Huijsduijnen R, Staple JK, et al. (1994). "RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.". Mol. Endocrinol. 8 (6): 757–70. doi:10.1210/me.8.6.757. PMID 7935491.  
  • Greiner EF, Kirfel J, Greschik H, et al. (1996). "Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor.". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10105–10. doi:10.1073/pnas.93.19.10105. PMID 8816759.  
  • Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily.". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Park HT, Baek SY, Kim BS, et al. (1997). "Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat.". Neurosci. Lett. 217 (1): 17–20. doi:10.1016/S0304-3940(96)13060-3. PMID 8905729.  
  • André E, Conquet F, Steinmayr M, et al. (1998). "Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice.". Embo J. 17 (14): 3867–77. doi:10.1093/emboj/17.14.3867. PMID 9670004.  
  • Greiner EF, Kirfel J, Greschik H, et al. (2000). "Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor.". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7160–5. doi:10.1073/pnas.97.13.7160. PMID 10860982.  
  • Gawlas K, Stunnenberg HG (2001). "Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1).". Biochim. Biophys. Acta 1494 (3): 236–41. PMID 11121580.  
  • Gawlas K, Stunnenberg HG (2001). "Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells.". Nucleic Acids Res. 29 (16): 3424–32. doi:10.1093/nar/29.16.3424. PMID 11504880.  
  • Stehlin C, Wurtz JM, Steinmetz A, et al. (2001). "X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.". Embo J. 20 (21): 5822–31. doi:10.1093/emboj/20.21.5822. PMID 11689423.  
  • Sumi Y, Yagita K, Yamaguchi S, et al. (2002). "Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus.". Neurosci. Lett. 320 (1-2): 13–6. doi:10.1016/S0304-3940(02)00011-3. PMID 11849752.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Stehlin-Gaon C, Willmann D, Zeyer D, et al. (2003). "All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta.". Nat. Struct. Biol. 10 (10): 820–5. doi:10.1038/nsb979. PMID 12958591.  
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.  

External links



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