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Retinoblastoma binding protein 6

PDB rendering based on 2c7h.
Available structures
2c7h
Identifiers
Symbols RBBP6; DKFZp686P0638; DKFZp761B2423; MY038; P2P-R; RBQ-1
External IDs OMIM600938 MGI894835 HomoloGene5039 GeneCards: RBBP6 Gene
RNA expression pattern
PBB GE RBBP6 205178 s at tn.png
PBB GE RBBP6 212781 at tn.png
PBB GE RBBP6 212783 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5930 19647
Ensembl ENSG00000122257 ENSMUSG00000073845
UniProt Q7Z6E9 n/a
RefSeq (mRNA) NM_006910 NM_011247
RefSeq (protein) NP_008841 NP_035377
Location (UCSC) Chr 16:
24.46 - 24.61 Mb
Chr 7:
122.76 - 122.77 Mb
PubMed search [1] [2]

Retinoblastoma-binding protein 6 is a protein that in humans is encoded by the RBBP6 gene.[1][2][3]

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.[3]

Interactions

RBBP6 has been shown to interact with Y box binding protein 1.[4]

References

  1. ^ Sakai Y, Saijo M, Coelho K, Kishino T, Niikawa N, Taya Y (Apr 1996). "cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product". Genomics 30 (1): 98–101. doi:10.1006/geno.1995.0017. PMID 8595913.  
  2. ^ Pugh DJ, Ab E, Faro A, Lutya PT, Hoffmann E, Rees DJ (Feb 2006). "DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways". BMC Struct Biol 6: 1. doi:10.1186/1472-6807-6-1. PMID 16396680.  
  3. ^ a b "Entrez Gene: RBBP6 retinoblastoma binding protein 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5930.  
  4. ^ Chibi, Moredreck; Meyer Mervin, Skepu Amanda, G Rees D Jasper, Moolman-Smook Johanna C, Pugh David J R (Dec. 2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. (England) 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID 18851979.  

Further reading

  • Simons A, Melamed-Bessudo C, Wolkowicz R, et al. (1997). "PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb.". Oncogene 14 (2): 145–55. doi:10.1038/sj.onc.1200825. PMID 9010216.  
  • Gao S, Witte MM, Scott RE (2002). "P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity.". J. Cell. Physiol. 191 (2): 145–54. doi:10.1002/jcp.10084. PMID 12064457.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Yoshitake Y, Nakatsura T, Monji M, et al. (2005). "Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis.". Clin. Cancer Res. 10 (19): 6437–48. doi:10.1158/1078-0432.CCR-04-0841. PMID 15475430.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Scott RE, White-Grindley E, Ruley HE, et al. (2005). "P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA.". J. Cell. Physiol. 204 (1): 99–105. doi:10.1002/jcp.20263. PMID 15617101.  
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
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