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Retinoblastoma binding protein 9
Identifiers
Symbols RBBP9; BOG; MGC9236; RBBP10
External IDs OMIM602908 MGI1347074 HomoloGene4816 GeneCards: RBBP9 Gene
Orthologs
Species Human Mouse
Entrez 10741 26450
Ensembl ENSG00000089050 n/a
UniProt O75884 n/a
RefSeq (mRNA) NM_006606 XM_992135
RefSeq (protein) NP_006597 XP_997229
Location (UCSC) Chr 20:
18.42 - 18.43 Mb
n/a
PubMed search [1] [2]

Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene.[1][2][3]

The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate.[3]

Interactions

RBBP9 has been shown to interact with Retinoblastoma protein.[1]

References

  1. ^ a b Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Sep 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nat Genet 19 (4): 371–4. doi:10.1038/1258. PMID 9697699.  
  2. ^ Woitach JT, Hong R, Keck CL, Zimonjic DB, Popescu NC, Thorgeirsson SS (Oct 1999). "Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization". Cytogenet Cell Genet 85 (3-4): 252–3. PMID 10449909.  
  3. ^ a b "Entrez Gene: RBBP9 retinoblastoma binding protein 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10741.  

Further reading

  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Chen JZ, Yang QS, Wang S, et al. (2003). "Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10.". Biochem. Genet. 40 (7-8): 273–82. doi:10.1023/A:1019886918029. PMID 12296629.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Chen J, Ji C, Gu S, et al. (2003). "Isolation and identification of a novel cDNA that encodes human yrdC protein.". J. Hum. Genet. 48 (4): 164–9. doi:10.1007/s10038-002-0001-3. PMID 12730717.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
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