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RDS-127: Wikis


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Systematic (IUPAC) name
CAS number 82668-32-4
ATC code  ?
PubChem 134064
Chemical data
Formula C17H27NO2 
Mol. mass 277.402 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

RDS-127 (2-(N,N-dipropylamino)-4,7-dimethoxyindane) is a drug which is used in scientific research. It acts as a non-selective dopamine agonist and also has some serotonin agonist and adrenergic agonist effects,[1][2][3][4] as well as some anticholinergic action,[5][6] and has both anorectic and pro-sexual effects in animal studies.[7][8]

See also


  1. ^ Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF (June 1982). "Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives". Archives Internationales De Pharmacodynamie Et De Thérapie 257 (2): 263–73. PMID 7114973. 
  2. ^ Arnerić SP, Long JP (May 1984). "Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions". The Journal of Pharmacy and Pharmacology 36 (5): 318–21. PMID 6145768. 
  3. ^ Clark JT, Smith ER (1986). "Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior". Physiology & Behavior 37 (1): 47–52. PMID 3737722. 
  4. ^ Rezaki YE, Ilhan M (1991). "Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae". Archives Internationales De Pharmacodynamie Et De Thérapie 310: 76–86. PMID 1685313. 
  5. ^ Sahin I, Ilhan M (1988). "The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig". Archives Internationales De Pharmacodynamie Et De Thérapie 296: 163–72. PMID 2907277. 
  6. ^ Sahin I, Tuncer M, Ilhan M (March 1990). "Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice". Archives Internationales De Physiologie Et De Biochimie 98 (1): 7–9. PMID 1692697. 
  7. ^ Arnerić SP, Roetker A, Long JP (September 1982). "Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists". Neuropharmacology 21 (9): 885–90. PMID 6897285. 
  8. ^ Kwong LL, Smith ER, Davidson JM, Peroutka SJ (October 1986). "Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors". Behavioral Neuroscience 100 (5): 664–8. PMID 2877677. 


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