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From Wikipedia, the free encyclopedia

V-rel reticuloendotheliosis viral oncogene homolog (avian)
Symbols REL; C-Rel
External IDs OMIM164910 MGI97897 HomoloGene2182 GeneCards: REL Gene
RNA expression pattern
PBB GE REL 206036 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5966 19696
Ensembl ENSG00000162924 ENSMUSG00000020275
UniProt Q04864 Q5SQ68
RefSeq (mRNA) NM_002908 NM_009044
RefSeq (protein) NP_002899 NP_033070
Location (UCSC) Chr 2:
60.96 - 61 Mb
Chr 11:
23.64 - 23.67 Mb
PubMed search [1] [2]

C-Rel proto-oncogene protein is a protein that in humans is encoded by the REL gene.[1] The protein encoded by the human REL gene is a member of the NF-κB family of transcription factors. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphomas and Hodgkin's lymphomas.


  1. ^ Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev 6 (5): 745-60. PMID 1577270.  

Further reading

  • Rayet B, Gélinas C (2000). "Aberrant rel/nfkb genes and activity in human cancer.". Oncogene 18 (49): 6938–47. doi:10.1038/sj.onc.1203221. PMID 10602468.  
  • Kunsch C, Ruben SM, Rosen CA (1992). "Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.". Mol. Cell. Biol. 12 (10): 4412–21. PMID 1406630.  
  • Neumann M, Tsapos K, Scheppler JA, et al. (1992). "Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B.". Oncogene 7 (11): 2095–104. PMID 1437141.  
  • Kochel T, Rice NR (1992). "v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro.". Oncogene 7 (3): 567–72. PMID 1549370.  
  • Kumar S, Rabson AB, Gélinas C (1992). "The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.". Mol. Cell. Biol. 12 (7): 3094–106. PMID 1620118.  
  • Lu D, Thompson JD, Gorski GK, et al. (1991). "Alterations at the rel locus in human lymphoma.". Oncogene 6 (7): 1235–41. PMID 1650444.  
  • Muchardt C, Seeler JS, Nirula A, et al. (1992). "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products.". J. Virol. 66 (1): 244–50. PMID 1727488.  
  • Hansen SK, Nerlov C, Zabel U, et al. (1992). "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.". Embo J. 11 (1): 205–13. PMID 1740106.  
  • Davis N, Ghosh S, Simmons DL, et al. (1991). "Rel-associated pp40: an inhibitor of the rel family of transcription factors.". Science 253 (5025): 1268–71. doi:10.1126/science.1891714. PMID 1891714.  
  • Lim MY, Davis N, Zhang JY, Bose HR (1990). "The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70.". Virology 175 (1): 149–60. doi:10.1016/0042-6822(90)90195-W. PMID 2155506.  
  • Brownell E, Mittereder N, Rice NR (1989). "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon.". Oncogene 4 (7): 935–42. PMID 2666912.  
  • Brownell E, O'Brien SJ, Nash WG, Rice N (1986). "Genetic characterization of human c-rel sequences.". Mol. Cell. Biol. 5 (10): 2826–31. PMID 3016517.  
  • Brownell E, Kozak CA, Fowle JR, et al. (1986). "Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat.". Am. J. Hum. Genet. 39 (2): 194–202. PMID 3529946.  
  • John S, Reeves RB, Lin JX, et al. (1995). "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.". Mol. Cell. Biol. 15 (3): 1786–96. PMID 7862168.  
  • Xu X, Gélinas C (1995). "The v-Rel oncoprotein complexes with new Rel- and RelA-related proteins in transformed cells.". Virology 207 (2): 362–8. doi:10.1006/viro.1995.1095. PMID 7886940.  
  • Mackman N (1994). "Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers.". J. Biol. Chem. 269 (42): 26363–7. PMID 7929355.  
  • Sif S, Gilmore TD (1994). "Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1.". J. Virol. 68 (11): 7131–8. PMID 7933095.  
  • Hansen SK, Baeuerle PA, Blasi F (1994). "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription.". Mol. Cell. Biol. 14 (4): 2593–603. PMID 8139561.  
  • Beg AA, Baldwin AS (1994). "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.". Oncogene 9 (5): 1487–92. PMID 8152812.  

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