The Full Wiki

More info on RELB

RELB: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
V-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)

PDB rendering based on 1zk9.
Available structures
1zk9, 1zka
Identifiers
Symbols RELB; I-REL
External IDs OMIM604758 MGI103289 HomoloGene4747 GeneCards: RELB Gene
RNA expression pattern
PBB GE RELB 205205 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5971 19698
Ensembl ENSG00000104856 ENSMUSG00000002983
UniProt Q01201 Q3U0K7
RefSeq (mRNA) NM_006509 NM_009046
RefSeq (protein) NP_006500 NP_033072
Location (UCSC) Chr 19:
50.2 - 50.23 Mb
Chr 7:
18.76 - 18.79 Mb
PubMed search [1] [2]

Transcription factor RelB is a protein that in humans is encoded by the RELB gene.[1]

Contents

Interactions

RELB has been shown to interact with NFKB2[2][3] and NFKB1.[2]

See also

Further reading

  • Taylor JP, Pomerantz R, Bagasra O, et al. (1992). "TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation.". EMBO J. 11 (9): 3395–403. PMID 1505523.  
  • Ruben SM, Klement JF, Coleman TA, et al. (1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.". Genes Dev. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.  
  • Liu J, Perkins ND, Schmid RM, Nabel GJ (1992). "Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.". J. Virol. 66 (6): 3883–7. PMID 1583734.  
  • Biswas DK, Salas TR, Wang F, et al. (1996). "A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter.". J. Virol. 69 (12): 7437–44. PMID 7494249.  
  • Jeang KT, Chun R, Lin NH, et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.". J. Virol. 67 (10): 6224–33. PMID 7690421.  
  • Alcamí J, Laín de Lera T, Folgueira L, et al. (1995). "Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.". EMBO J. 14 (7): 1552–60. PMID 7729429.  
  • Majello B, De Luca P, Hagen G, et al. (1995). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.". Nucleic Acids Res. 22 (23): 4914–21. doi:10.1093/nar/22.23.4914. PMID 7800480.  
  • Taylor JP, Pomerantz RJ, Oakes JW, et al. (1995). "A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat.". Oncogene 10 (2): 395–400. PMID 7838536.  
  • Westendorp MO, Shatrov VA, Schulze-Osthoff K, et al. (1995). "HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.". EMBO J. 14 (3): 546–54. PMID 7859743.  
  • Scala G, Ruocco MR, Ambrosino C, et al. (1994). "The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein.". J. Exp. Med. 179 (3): 961–71. doi:10.1084/jem.179.3.961. PMID 8113688.  
  • Bours V, Azarenko V, Dejardin E, Siebenlist U (1994). "Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins.". Oncogene 9 (6): 1699–702. PMID 8183565.  
  • Deloukas P, Dauwerse JG, van Ommen GJ, van Loon AP (1994). "The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12.". Genomics 19 (3): 592–4. doi:10.1006/geno.1994.1115. PMID 8188306.  
  • Westendorp MO, Li-Weber M, Frank RW, Krammer PH (1994). "Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.". J. Virol. 68 (7): 4177–85. PMID 8207793.  
  • Dobrzanski P, Ryseck RP, Bravo R (1993). "Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif.". Mol. Cell. Biol. 13 (3): 1572–82. PMID 8441398.  
  • Harhaj E, Blaney J, Millhouse S, Sun SC (1996). "Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR.". Virology 216 (1): 284–7. doi:10.1006/viro.1996.0062. PMID 8615004.  
  • Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.". J. Virol. 70 (3): 1384–9. PMID 8627654.  
  • Demarchi F, d'Adda di Fagagna F, Falaschi A, Giacca M (1996). "Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1.". J. Virol. 70 (7): 4427–37. PMID 8676466.  
  • Beauparlant P, Kwon H, Clarke M, et al. (1996). "Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication.". J. Virol. 70 (9): 5777–85. PMID 8709193.  
  • Ramazzotti E, Vignoli M, Re MC, et al. (1996). "Enhanced nuclear factor-kappa B activation induced by tumour necrosis factor-alpha in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein.". AIDS 10 (5): 455–61. doi:10.1097/00002030-199605000-00002. PMID 8724035.  

References

  1. ^ Bours V, Burd PR, Brown K, Villalobos J, Park S, Ryseck RP, Bravo R, Kelly K, Siebenlist U (Feb 1992). "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site". Mol Cell Biol 12 (2): 685–95. PMID 1531086.  
  2. ^ a b Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14755267.  
  3. ^ Thornburg, Natalie J; Pathmanathan Rajadurai, Raab-Traub Nancy (Dec. 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Res. (United States) 63 (23): 8293–301. ISSN 0008-5472. PMID 14678988.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message