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V-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)

PDB rendering based on 1zk9.
Available structures
1zk9, 1zka
Symbols RELB; I-REL
External IDs OMIM604758 MGI103289 HomoloGene4747 GeneCards: RELB Gene
RNA expression pattern
PBB GE RELB 205205 at tn.png
More reference expression data
Species Human Mouse
Entrez 5971 19698
Ensembl ENSG00000104856 ENSMUSG00000002983
UniProt Q01201 Q3U0K7
RefSeq (mRNA) NM_006509 NM_009046
RefSeq (protein) NP_006500 NP_033072
Location (UCSC) Chr 19:
50.2 - 50.23 Mb
Chr 7:
18.76 - 18.79 Mb
PubMed search [1] [2]

Transcription factor RelB is a protein that in humans is encoded by the RELB gene.[1]



RELB has been shown to interact with NFKB2[2][3] and NFKB1.[2]

See also

Further reading

  • Taylor JP, Pomerantz R, Bagasra O, et al. (1992). "TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation.". EMBO J. 11 (9): 3395–403. PMID 1505523.  
  • Ruben SM, Klement JF, Coleman TA, et al. (1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.". Genes Dev. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.  
  • Liu J, Perkins ND, Schmid RM, Nabel GJ (1992). "Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.". J. Virol. 66 (6): 3883–7. PMID 1583734.  
  • Biswas DK, Salas TR, Wang F, et al. (1996). "A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter.". J. Virol. 69 (12): 7437–44. PMID 7494249.  
  • Jeang KT, Chun R, Lin NH, et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.". J. Virol. 67 (10): 6224–33. PMID 7690421.  
  • Alcamí J, Laín de Lera T, Folgueira L, et al. (1995). "Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.". EMBO J. 14 (7): 1552–60. PMID 7729429.  
  • Majello B, De Luca P, Hagen G, et al. (1995). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.". Nucleic Acids Res. 22 (23): 4914–21. doi:10.1093/nar/22.23.4914. PMID 7800480.  
  • Taylor JP, Pomerantz RJ, Oakes JW, et al. (1995). "A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat.". Oncogene 10 (2): 395–400. PMID 7838536.  
  • Westendorp MO, Shatrov VA, Schulze-Osthoff K, et al. (1995). "HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.". EMBO J. 14 (3): 546–54. PMID 7859743.  
  • Scala G, Ruocco MR, Ambrosino C, et al. (1994). "The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein.". J. Exp. Med. 179 (3): 961–71. doi:10.1084/jem.179.3.961. PMID 8113688.  
  • Bours V, Azarenko V, Dejardin E, Siebenlist U (1994). "Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins.". Oncogene 9 (6): 1699–702. PMID 8183565.  
  • Deloukas P, Dauwerse JG, van Ommen GJ, van Loon AP (1994). "The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12.". Genomics 19 (3): 592–4. doi:10.1006/geno.1994.1115. PMID 8188306.  
  • Westendorp MO, Li-Weber M, Frank RW, Krammer PH (1994). "Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.". J. Virol. 68 (7): 4177–85. PMID 8207793.  
  • Dobrzanski P, Ryseck RP, Bravo R (1993). "Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif.". Mol. Cell. Biol. 13 (3): 1572–82. PMID 8441398.  
  • Harhaj E, Blaney J, Millhouse S, Sun SC (1996). "Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR.". Virology 216 (1): 284–7. doi:10.1006/viro.1996.0062. PMID 8615004.  
  • Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.". J. Virol. 70 (3): 1384–9. PMID 8627654.  
  • Demarchi F, d'Adda di Fagagna F, Falaschi A, Giacca M (1996). "Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1.". J. Virol. 70 (7): 4427–37. PMID 8676466.  
  • Beauparlant P, Kwon H, Clarke M, et al. (1996). "Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication.". J. Virol. 70 (9): 5777–85. PMID 8709193.  
  • Ramazzotti E, Vignoli M, Re MC, et al. (1996). "Enhanced nuclear factor-kappa B activation induced by tumour necrosis factor-alpha in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein.". AIDS 10 (5): 455–61. doi:10.1097/00002030-199605000-00002. PMID 8724035.  


  1. ^ Bours V, Burd PR, Brown K, Villalobos J, Park S, Ryseck RP, Bravo R, Kelly K, Siebenlist U (Feb 1992). "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site". Mol Cell Biol 12 (2): 685–95. PMID 1531086.  
  2. ^ a b Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14755267.  
  3. ^ Thornburg, Natalie J; Pathmanathan Rajadurai, Raab-Traub Nancy (Dec. 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Res. (United States) 63 (23): 8293–301. ISSN 0008-5472. PMID 14678988.  


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