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Regulatory factor X, 1 (influences HLA class II expression)

PDB rendering based on 1dp7.
Available structures
Symbols RFX1; EF-C
External IDs OMIM600006 MGI105982 HomoloGene2189 GeneCards: RFX1 Gene
RNA expression pattern
PBB GE RFX1 206321 at tn.png
PBB GE RFX1 222012 at tn.png
More reference expression data
Species Human Mouse
Entrez 5989 19724
Ensembl ENSG00000132005 ENSMUSG00000031706
UniProt P22670 Q3V383
RefSeq (mRNA) NM_002918 NM_009055
RefSeq (protein) NP_002909 NP_033081
Location (UCSC) Chr 19:
13.93 - 13.98 Mb
Chr 8:
86.96 - 86.99 Mb
PubMed search [1] [2]

MHC class II regulatory factor RFX1 is a protein that in humans is encoded by the RFX1 gene.[1][2][3]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.[3]



RFX1 has been shown to interact with Abl gene.[4]


  1. ^ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics 13 (4): 1307–10. PMID 1505960.  
  2. ^ Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B (Feb 1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol Cell Biol 14 (2): 1230–44. PMID 8289803.  
  3. ^ a b "Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)".  
  4. ^ Agami, R; Shaul Y (Apr. 1998). "The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes". Oncogene (ENGLAND) 16 (14): 1779–88. doi:10.1038/sj.onc.1201708. ISSN 0950-9232. PMID 9583676.  

Further reading

  • Herrero Sanchez C, Reith W, Silacci P, Mach B (1992). "The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.". Mol. Cell. Biol. 12 (9): 4076–83. PMID 1508204.  
  • Reith W, Herrero-Sanchez C, Kobr M, et al. (1991). "MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain.". Genes Dev. 4 (9): 1528–40. doi:10.1101/gad.4.9.1528. PMID 2253877.  
  • Sáfrány G, Perry RP (1993). "Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element.". Gene 132 (2): 279–83. doi:10.1016/0378-1119(93)90208-K. PMID 8224874.  
  • Siegrist CA, Durand B, Emery P, et al. (1993). "RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer.". Mol. Cell. Biol. 13 (10): 6375–84. PMID 8413236.  
  • Emery P, Durand B, Mach B, Reith W (1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.". Nucleic Acids Res. 24 (5): 803–7. doi:10.1093/nar/24.5.803. PMID 8600444.  
  • Doyle J, Hoffman S, Ucla C, et al. (1996). "Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.". Genomics 35 (1): 227–30. doi:10.1006/geno.1996.0343. PMID 8661125.  
  • Agami R, Shaul Y (1998). "The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes.". Oncogene 16 (14): 1779–88. doi:10.1038/sj.onc.1201708. PMID 9583676.  
  • Katan-Khaykovich Y, Shaul Y (1998). "RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes.". J. Biol. Chem. 273 (38): 24504–12. doi:10.1074/jbc.273.38.24504. PMID 9733744.  
  • Iwama A, Pan J, Zhang P, et al. (1999). "Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.". Mol. Cell. Biol. 19 (6): 3940–50. PMID 10330134.  
  • Zajac-Kaye M, Ben-Baruch N, Kastanos E, et al. (2000). "Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells.". Biochem. J. 345 Pt 3: 535–41. doi:10.1042/0264-6021:3450535. PMID 10642512.  
  • Katan-Khaykovich Y, Shaul Y (2001). "Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism.". Eur. J. Biochem. 268 (10): 3108–16. doi:10.1046/j.1432-1327.2001.02211.x. PMID 11358531.  
  • Morotomi-Yano K, Yano K, Saito H, et al. (2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.". J. Biol. Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID 11682486.  
  • Sengupta PK, Fargo J, Smith BD (2002). "The RFX family interacts at the collagen (COL1A2) start site and represses transcription.". J. Biol. Chem. 277 (28): 24926–37. doi:10.1074/jbc.M111712200. PMID 11986307.  
  • Nakayama A, Murakami H, Maeyama N, et al. (2003). "Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.". J. Biol. Chem. 278 (1): 233–40. doi:10.1074/jbc.M209574200. PMID 12411430.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin.". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.  
  • Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.". Arch. Dermatol. Res. 295 (11): 482–9. doi:10.1007/s00403-004-0456-5. PMID 15024578.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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