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Regulatory factor X, 2 (influences HLA class II expression)
Symbols RFX2; FLJ14226
External IDs OMIM142765 MGI106583 HomoloGene30980 GeneCards: RFX2 Gene
RNA expression pattern
PBB GE RFX2 208031 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5990 19725
Ensembl ENSG00000087903 ENSMUSG00000024206
UniProt P48378 P48379
RefSeq (mRNA) NM_000635 NM_009056
RefSeq (protein) NP_000626 NP_033082
Location (UCSC) Chr 19:
5.94 - 6.06 Mb
Chr 17:
56.46 - 56.52 Mb
PubMed search [1] [2]

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.[1][2]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.[2]


  1. ^ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics 13 (4): 1307-10. PMID 1505960.  
  2. ^ a b "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)".  

Further reading

  • Reith W, Ucla C, Barras E, et al. (1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.". Mol. Cell. Biol. 14 (2): 1230–44. PMID 8289803.  
  • Doyle J, Hoffman S, Ucla C, et al. (1996). "Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.". Genomics 35 (1): 227–30. doi:10.1006/geno.1996.0343. PMID 8661125.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Iwama A, Pan J, Zhang P, et al. (1999). "Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.". Mol. Cell. Biol. 19 (6): 3940–50. PMID 10330134.  
  • Morotomi-Yano K, Yano K, Saito H, et al. (2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.". J. Biol. Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID 11682486.  
  • Sengupta PK, Fargo J, Smith BD (2002). "The RFX family interacts at the collagen (COL1A2) start site and represses transcription.". J. Biol. Chem. 277 (28): 24926–37. doi:10.1074/jbc.M111712200. PMID 11986307.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.". Arch. Dermatol. Res. 295 (11): 482–9. doi:10.1007/s00403-004-0456-5. PMID 15024578.  
  • Horvath GC, Kistler WS, Kistler MK (2005). "RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis.". Biol. Reprod. 71 (5): 1551–9. doi:10.1095/biolreprod.104.032268. PMID 15229132.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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