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Rh family, B glycoprotein
Symbols RHBG; SLC42A2
External IDs OMIM607079 MGI1927379 HomoloGene9469 GeneCards: RHBG Gene
RNA expression pattern
PBB GE RHBG 220510 at tn.png
More reference expression data
Species Human Mouse
Entrez 57127 58176
Ensembl ENSG00000132677 ENSMUSG00000001417
UniProt n/a n/a
RefSeq (mRNA) NM_020407 NM_021375
RefSeq (protein) NP_065140 NP_067350
Location (UCSC) Chr 1:
154.61 - 154.62 Mb
Chr 3:
88.33 - 88.34 Mb
PubMed search [1] [2]

Rh family, B glycoprotein, also known as RHBG, is a protein which in humans is encoded by the RHBG gene.[1][2]


RHBG and RHCG are non-erythroid members of the Rhesus (Rh) protein family that are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. Rh family proteins are all predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini.[1]


  1. ^ a b "Entrez Gene: RHBG Rh family, B glycoprotein".  
  2. ^ Liu Z, Peng J, Mo R, Hui C, Huang CH (January 2001). "Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals". J. Biol. Chem. 276 (2): 1424–33. doi:10.1074/jbc.M007528200. PMID 11024028.  

Further reading

  • Huang CH, Liu PZ (2001). "New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues.". Blood Cells Mol. Dis. 27 (1): 90–101. doi:10.1006/bcmd.2000.0355. PMID 11358367.  
  • Liu Z, Chen Y, Mo R, et al. (2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis.". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913.  
  • Liu Z, Peng J, Mo R, et al. (2001). "Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals.". J. Biol. Chem. 276 (2): 1424–33. doi:10.1074/jbc.M007528200. PMID 11024028.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Ludewig U (2005). "Electroneutral ammonium transport by basolateral rhesus B glycoprotein.". J. Physiol. (Lond.) 559 (Pt 3): 751–9. doi:10.1113/jphysiol.2004.067728. PMID 15284342.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Lopez C, Métral S, Eladari D, et al. (2005). "The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.". J. Biol. Chem. 280 (9): 8221–8. doi:10.1074/jbc.M413351200. PMID 15611082.  
  • Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, et al. (2006). "Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells.". Biochem. J. 391 (Pt 1): 33–40. doi:10.1042/BJ20050657. PMID 15929723.  
  • Huang CH, Peng J (2005). "Evolutionary conservation and diversification of Rh family genes and proteins.". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15512–7. doi:10.1073/pnas.0507886102. PMID 16227429.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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