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Ras homolog gene family, member B

PDB rendering based on 2fv8.
Available structures
Symbols RHOB; ARH6; ARHB; MST081; MSTP081; RHOH6
External IDs OMIM165370 MGI107949 HomoloGene68377 GeneCards: RHOB Gene
EC number
RNA expression pattern
PBB GE RHOB 212099 at tn.png
More reference expression data
Species Human Mouse
Entrez 388 11852
Ensembl ENSG00000143878 ENSMUSG00000054364
UniProt P62745 Q3TIC2
RefSeq (mRNA) NM_004040 NM_007483
RefSeq (protein) NP_004031 NP_031509
Location (UCSC) Chr 2:
20.51 - 20.51 Mb
Chr 12:
8.53 - 8.53 Mb
PubMed search [1] [2]

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.[1][2]

RHOB is a member of the Rho GTP-binding protein family.[3]



RHOB has been shown to interact with CIT,[4] ARHGEF3,[5] ARHGDIG[6] and RHPN2.[7]


  1. ^ "Entrez Gene: RHOB ras homolog gene family, member B".  
  2. ^ Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human rho cDNAs clone 6 and clone 9". Nucleic acids research 16 (6): 2717. doi:10.1093/nar/16.6.2717. PMID 3283705. PMC 336400.  
  3. ^ Wennerberg K, Der CJ (March 2004). "Rho-family GTPases: it's not only Rac and Rho (and I like it)". Journal of cell science 117 (Pt 8): 1301–12. doi:10.1242/jcs.01118. PMID 15020670.  
  4. ^ Madaule, P; Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S (Dec. 1995). "A novel partner for the GTP-bound forms of rho and rac". FEBS Lett. (NETHERLANDS) 377 (2): 243–8. ISSN 0014-5793. PMID 8543060.  
  5. ^ Arthur, William T; Ellerbroek Shawn M, Der Channing J, Burridge Keith, Wennerberg Krister (Nov. 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. (United States) 277 (45): 42964–72. doi:10.1074/jbc.M207401200. ISSN 0021-9258. PMID 12221096.  
  6. ^ Zalcman, G; Closson V, Camonis J, Honoré N, Rousseau-Merck M F, Tavitian A, Olofsson B (Nov. 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. (UNITED STATES) 271 (48): 30366–74. ISSN 0021-9258. PMID 8939998.  
  7. ^ Mircescu, Hortensia; Steuve Séverine, Savonet Valérie, Degraef Chantal, Mellor Harry, Dumont Jacques E, Maenhaut Carine, Pirson Isabelle (Dec. 2002). "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP". Eur. J. Biochem. (Germany) 269 (24): 6241–9. ISSN 0014-2956. PMID 12473120.  

Further reading

  • Casey PJ, Seabra MC (1996). "Protein prenyltransferases.". J. Biol. Chem. 271 (10): 5289–92. doi:10.1074/jbc.271.10.5289. PMID 8621375.  
  • Adamson P, Marshall CJ, Hall A, Tilbrook PA (1992). "Post-translational modifications of p21rho proteins.". J. Biol. Chem. 267 (28): 20033–8. PMID 1400319.  
  • Cannizzaro LA, Madaule P, Hecht F, et al. (1990). "Chromosome localization of human ARH genes, a ras-related gene family.". Genomics 6 (2): 197–203. doi:10.1016/0888-7543(90)90557-B. PMID 2407642.  
  • Chardin P, Madaule P, Tavitian A (1988). "Coding sequence of human rho cDNAs clone 6 and clone 9.". Nucleic Acids Res. 16 (6): 2717. doi:10.1093/nar/16.6.2717. PMID 3283705.  
  • Madaule P, Axel R (1985). "A novel ras-related gene family.". Cell 41 (1): 31–40. doi:10.1016/0092-8674(85)90058-3. PMID 3888408.  
  • Robertson D, Paterson HF, Adamson P, et al. (1995). "Ultrastructural localization of ras-related proteins using epitope-tagged plasmids.". J. Histochem. Cytochem. 43 (5): 471–80. PMID 7537292.  
  • Armstrong SA, Hannah VC, Goldstein JL, Brown MS (1995). "CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB.". J. Biol. Chem. 270 (14): 7864–8. doi:10.1074/jbc.270.14.7864. PMID 7713879.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Zalcman G, Closson V, Camonis J, et al. (1997). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG.". J. Biol. Chem. 271 (48): 30366–74. doi:10.1074/jbc.271.48.30366. PMID 8939998.  
  • Mellor H, Flynn P, Nobes CD, et al. (1998). "PRK1 is targeted to endosomes by the small GTPase, RhoB.". J. Biol. Chem. 273 (9): 4811–4. doi:10.1074/jbc.273.9.4811. PMID 9478917.  
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.  
  • Liu JP, Jessell TM (1999). "A role for rhoB in the delamination of neural crest cells from the dorsal neural tube.". Development 125 (24): 5055–67. PMID 9811589.  
  • Gampel A, Parker PJ, Mellor H (2000). "Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB.". Curr. Biol. 9 (17): 955–8. doi:10.1016/S0960-9822(99)80422-9. PMID 10508588.  
  • Matarrese P, Conti L, Varano B, et al. (2000). "The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly.". Cell Death Differ. 7 (1): 25–36. doi:10.1038/sj.cdd.4400616. PMID 10713718.  
  • Liu A, Du W, Liu JP, et al. (2000). "RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors.". Mol. Cell. Biol. 20 (16): 6105–13. doi:10.1128/MCB.20.16.6105-6113.2000. PMID 10913192.  
  • Michaelson D, Silletti J, Murphy G, et al. (2001). "Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding.". J. Cell Biol. 152 (1): 111–26. doi:10.1083/jcb.152.1.111. PMID 11149925.  
  • Liu Ax , Cerniglia GJ, Bernhard EJ, Prendergast GC (2001). "RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6192–7. doi:10.1073/pnas.111137198. PMID 11353846.  
  • Diviani D, Soderling J, Scott JD (2001). "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.". J. Biol. Chem. 276 (47): 44247–57. doi:10.1074/jbc.M106629200. PMID 11546812.  
  • Adnane J, Seijo E, Chen Z, et al. (2002). "RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.". J. Biol. Chem. 277 (10): 8500–7. doi:10.1074/jbc.M104367200. PMID 11741970.  

See also



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