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Ribonuclease, RNase A family, 1 (pancreatic)

PDB rendering based on 1dza.
Available structures
1dza, 1e21, 1h8x, 1z7x
Identifiers
Symbols RNASE1; MGC12408; RIB1; RNS1
External IDs OMIM180440 MGI97919 HomoloGene7919 GeneCards: RNASE1 Gene
RNA expression pattern
PBB GE RNASE1 201785 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6035 19752
Ensembl ENSG00000129538 ENSMUSG00000035896
UniProt P07998 Q8C6G3
RefSeq (mRNA) NM_002933 NM_011271
RefSeq (protein) NP_002924 NP_035401
Location (UCSC) Chr 14:
20.34 - 20.34 Mb
Chr 14:
50.07 - 50.07 Mb
PubMed search [1] [2]

Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[1][2]

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]

References

  1. ^ Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI (Mar 1996). "[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]". Bioorg Khim 21 (9): 691-4. PMID 8588814.  
  2. ^ a b "Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6035.  

Further reading

  • Nogués MV, Vilanova M, Cuchillo CM (1996). "Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites.". Biochim. Biophys. Acta 1253 (1): 16–24. PMID 7492594.  
  • Schienman JE, Holt RA, Auerbach MR, Stewart CB (2006). "Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys.". Mol. Biol. Evol. 23 (8): 1465–79. doi:10.1093/molbev/msl025. PMID 16751256.  
  • Sakakibara R, Hashida K, Kitahara T, Ishiguro M (1992). "Characterization of a unique nonsecretory ribonuclease from urine of pregnant women.". J. Biochem. 111 (3): 325–30. PMID 1587793.  
  • Haugg M, Schein CH (1992). "The DNA sequences of the human and hamster secretory ribonucleases determined with the polymerase chain reaction (PCR).". Nucleic Acids Res. 20 (3): 612. doi:10.1093/nar/20.3.612. PMID 1741299.  
  • Sakakibara R, Hashida K, Tominaga N, et al. (1991). "A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease.". Chem. Pharm. Bull. 39 (1): 146–9. PMID 2049798.  
  • Mizuta K, Awazu S, Yasuda T, Kishi K (1990). "Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases.". Arch. Biochem. Biophys. 281 (1): 144–51. doi:10.1016/0003-9861(90)90424-W. PMID 2383019.  
  • Beintema JJ, Blank A, Schieven GL, et al. (1989). "Differences in glycosylation pattern of human secretory ribonucleases.". Biochem. J. 255 (2): 501–5. PMID 3202829.  
  • Beintema JJ, Wietzes P, Weickmann JL, Glitz DG (1984). "The amino acid sequence of human pancreatic ribonuclease.". Anal. Biochem. 136 (1): 48–64. doi:10.1016/0003-2697(84)90306-3. PMID 6201087.  
  • Russo N, de Nigris M, Ciardiello A, et al. (1995). "Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease.". FEBS Lett. 369 (2-3): 352. doi:10.1016/0014-5793(95)96890-G. PMID 7649283.  
  • Seno M, Futami J, Kosaka M, et al. (1994). "Nucleotide sequence encoding human pancreatic ribonuclease.". Biochim. Biophys. Acta 1218 (3): 466–8. PMID 8049276.  
  • Yasuda T, Nadano D, Takeshita H, Kishi K (1994). "Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases.". Biochem. J. 296 ( Pt 3): 617–25. PMID 8280059.  
  • Papageorgiou AC, Shapiro R, Acharya KR (1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution.". Embo J. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMID 9311977.  
  • Klink TA, Woycechowsky KJ, Taylor KM, Raines RT (2000). "Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A.". Eur. J. Biochem. 267 (2): 566–72. doi:10.1046/j.1432-1327.2000.01037.x. PMID 10632727.  
  • Pous J, Canals A, Terzyan SS, et al. (2000). "Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases.". J. Mol. Biol. 303 (1): 49–60. doi:10.1006/jmbi.2000.4506. PMID 11021969.  
  • Pous J, Mallorquí-Fernández G, Peracaula R, et al. (2001). "Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution.". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 4): 498–505. doi:10.1107/S0907444901001147. PMID 11264578.  
  • Gaur D, Swaminathan S, Batra JK (2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants.". J. Biol. Chem. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.  
  • Futami J, Maeda T, Kitazoe M, et al. (2001). "Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups.". Biochemistry 40 (25): 7518–24. doi:10.1021/bi010248g. PMID 11412105.  
  • Canals A, Pous J, Guasch A, et al. (2002). "The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization.". Structure 9 (10): 967–76. doi:10.1016/S0969-2126(01)00659-1. PMID 11591351.  
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