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Ribonuclease, RNase A family, 1 (pancreatic)

PDB rendering based on 1dza.
Available structures
1dza, 1e21, 1h8x, 1z7x
Symbols RNASE1; MGC12408; RIB1; RNS1
External IDs OMIM180440 MGI97919 HomoloGene7919 GeneCards: RNASE1 Gene
RNA expression pattern
PBB GE RNASE1 201785 at tn.png
More reference expression data
Species Human Mouse
Entrez 6035 19752
Ensembl ENSG00000129538 ENSMUSG00000035896
UniProt P07998 Q8C6G3
RefSeq (mRNA) NM_002933 NM_011271
RefSeq (protein) NP_002924 NP_035401
Location (UCSC) Chr 14:
20.34 - 20.34 Mb
Chr 14:
50.07 - 50.07 Mb
PubMed search [1] [2]

Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[1][2]

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]


  1. ^ Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI (Mar 1996). "[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]". Bioorg Khim 21 (9): 691-4. PMID 8588814.  
  2. ^ a b "Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)".  

Further reading

  • Nogués MV, Vilanova M, Cuchillo CM (1996). "Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites.". Biochim. Biophys. Acta 1253 (1): 16–24. PMID 7492594.  
  • Schienman JE, Holt RA, Auerbach MR, Stewart CB (2006). "Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys.". Mol. Biol. Evol. 23 (8): 1465–79. doi:10.1093/molbev/msl025. PMID 16751256.  
  • Sakakibara R, Hashida K, Kitahara T, Ishiguro M (1992). "Characterization of a unique nonsecretory ribonuclease from urine of pregnant women.". J. Biochem. 111 (3): 325–30. PMID 1587793.  
  • Haugg M, Schein CH (1992). "The DNA sequences of the human and hamster secretory ribonucleases determined with the polymerase chain reaction (PCR).". Nucleic Acids Res. 20 (3): 612. doi:10.1093/nar/20.3.612. PMID 1741299.  
  • Sakakibara R, Hashida K, Tominaga N, et al. (1991). "A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease.". Chem. Pharm. Bull. 39 (1): 146–9. PMID 2049798.  
  • Mizuta K, Awazu S, Yasuda T, Kishi K (1990). "Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases.". Arch. Biochem. Biophys. 281 (1): 144–51. doi:10.1016/0003-9861(90)90424-W. PMID 2383019.  
  • Beintema JJ, Blank A, Schieven GL, et al. (1989). "Differences in glycosylation pattern of human secretory ribonucleases.". Biochem. J. 255 (2): 501–5. PMID 3202829.  
  • Beintema JJ, Wietzes P, Weickmann JL, Glitz DG (1984). "The amino acid sequence of human pancreatic ribonuclease.". Anal. Biochem. 136 (1): 48–64. doi:10.1016/0003-2697(84)90306-3. PMID 6201087.  
  • Russo N, de Nigris M, Ciardiello A, et al. (1995). "Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease.". FEBS Lett. 369 (2-3): 352. doi:10.1016/0014-5793(95)96890-G. PMID 7649283.  
  • Seno M, Futami J, Kosaka M, et al. (1994). "Nucleotide sequence encoding human pancreatic ribonuclease.". Biochim. Biophys. Acta 1218 (3): 466–8. PMID 8049276.  
  • Yasuda T, Nadano D, Takeshita H, Kishi K (1994). "Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases.". Biochem. J. 296 ( Pt 3): 617–25. PMID 8280059.  
  • Papageorgiou AC, Shapiro R, Acharya KR (1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution.". Embo J. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMID 9311977.  
  • Klink TA, Woycechowsky KJ, Taylor KM, Raines RT (2000). "Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A.". Eur. J. Biochem. 267 (2): 566–72. doi:10.1046/j.1432-1327.2000.01037.x. PMID 10632727.  
  • Pous J, Canals A, Terzyan SS, et al. (2000). "Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases.". J. Mol. Biol. 303 (1): 49–60. doi:10.1006/jmbi.2000.4506. PMID 11021969.  
  • Pous J, Mallorquí-Fernández G, Peracaula R, et al. (2001). "Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution.". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 4): 498–505. doi:10.1107/S0907444901001147. PMID 11264578.  
  • Gaur D, Swaminathan S, Batra JK (2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants.". J. Biol. Chem. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.  
  • Futami J, Maeda T, Kitazoe M, et al. (2001). "Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups.". Biochemistry 40 (25): 7518–24. doi:10.1021/bi010248g. PMID 11412105.  
  • Canals A, Pous J, Guasch A, et al. (2002). "The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization.". Structure 9 (10): 967–76. doi:10.1016/S0969-2126(01)00659-1. PMID 11591351.  


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