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ROS1 (gene): Wikis


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V-ros UR2 sarcoma virus oncogene homolog 1 (avian)
Symbols ROS1; MCF3; ROS
External IDs OMIM165020 MGI97999 HomoloGene2207 GeneCards: ROS1 Gene
RNA expression pattern
PBB GE ROS1 207569 at tn.png
More reference expression data
Species Human Mouse
Entrez 6098 19886
Ensembl ENSG00000047936 ENSMUSG00000019893
UniProt P08922 n/a
RefSeq (mRNA) NM_002944 NM_011282
RefSeq (protein) NP_002935 NP_035412
Location (UCSC) Chr 6:
117.72 - 117.85 Mb
Chr 10:
51.73 - 51.88 Mb
PubMed search [1] [2]

Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.[1][2]

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.[2]


ROS1 (gene) has been shown to interact with PTPN6.[3]


  1. ^ Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenet Cell Genet 60 (2): 114–6. PMID 1611909.  
  2. ^ a b "Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)".  
  3. ^ Keilhack, H; Müller M, Böhmer S A, Frank C, Weidner K M, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Günther B, Müller T, Birchmeier C, Böhmer F D (Jan. 2001). "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". J. Cell Biol. (United States) 152 (2): 325–34. ISSN 0021-9525. PMID 11266449.  

Further reading

  • Birchmeier C, O'Neill K, Riggs M, Wigler M (1990). "Characterization of ROS1 cDNA from a human glioblastoma cell line.". Proc. Natl. Acad. Sci. U.S.A. 87 (12): 4799–803. doi:10.1073/pnas.87.12.4799. PMID 2352949.  
  • Sharma S, Birchmeier C, Nikawa J, et al. (1990). "Characterization of the ros1-gene products expressed in human glioblastoma cell lines.". Oncogene Res. 5 (2): 91–100. PMID 2691958.  
  • Birchmeier C, Sharma S, Wigler M (1988). "Expression and rearrangement of the ROS1 gene in human glioblastoma cells.". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9270–4. doi:10.1073/pnas.84.24.9270. PMID 2827175.  
  • Matsushime H, Wang LH, Shibuya M (1987). "Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule.". Mol. Cell. Biol. 6 (8): 3000–4. PMID 3023956.  
  • Satoh H, Yoshida MC, Matsushime H, et al. (1987). "Regional localization of the human c-ros-1 on 6q22 and flt on 13q12.". Jpn. J. Cancer Res. 78 (8): 772–5. PMID 3115921.  
  • Birchmeier C, Birnbaum D, Waitches G, et al. (1986). "Characterization of an activated human ros gene.". Mol. Cell. Biol. 6 (9): 3109–16. PMID 3785223.  
  • Sonnenberg-Riethmacher E, Walter B, Riethmacher D, et al. (1996). "The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis.". Genes Dev. 10 (10): 1184–93. doi:10.1101/gad.10.10.1184. PMID 8675006.  
  • Zeng L, Sachdev P, Yan L, et al. (2001). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.". Mol. Cell. Biol. 20 (24): 9212–24. doi:10.1128/MCB.20.24.9212-9224.2000. PMID 11094073.  
  • Keilhack H, Müller M, Böhmer SA, et al. (2001). "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.". J. Cell Biol. 152 (2): 325–34. doi:10.1083/jcb.152.2.325. PMID 11266449.  
  • Charest A, Kheifets V, Park J, et al. (2003). "Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma.". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 916–21. doi:10.1073/pnas.242741799. PMID 12538861.  
  • Charest A, Lane K, McMahon K, et al. (2003). "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).". Genes Chromosomes Cancer 37 (1): 58–71. doi:10.1002/gcc.10207. PMID 12661006.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Légaré C, Sullivan R (2005). "Expression and localization of c-ros oncogene along the human excurrent duct.". Mol. Hum. Reprod. 10 (9): 697–703. doi:10.1093/molehr/gah087. PMID 15235104.  
  • Biskup C, Böhmer A, Pusch R, et al. (2005). "Visualization of SHP-1-target interaction.". J. Cell. Sci. 117 (Pt 21): 5165–78. doi:10.1242/jcs.01397. PMID 15456853.  
  • Girish V, Sachdeva N, Minz RW, et al. (2006). "Bcl2 and ROS1 expression in human meningiomas: an analysis with respect to histological subtype.". Indian journal of pathology & microbiology 48 (3): 325–30. PMID 16761743.  


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