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RTI-31: Wikis

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RTI-31
Systematic (IUPAC) name
methyl (1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Identifiers
CAS number 130342-80-2
ATC code  ?
PubChem 131195
Chemical data
Formula C16H20ClNO2 
Mol. mass 293.12 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

(–)-2β-Carbomethoxy-3β-(4'-chlorophenyl)tropane (RTI-31) is a synthetic analog of cocaine that acts as a stimulant.[1] Semi-synthesis of this compound is dependent upon the availability of cocaine starting material.

Further chemical modification of RTI-31 leads to novel chemical entities, some of them are highly potent, and one of them has been reported as lasting for three days.[2]

RTI-31 is also used in the synthesis of other compounds such as RTI-113 and RTI-336.

References

  1. ^ Wee, S.; Carroll, F.; Woolverton, W. (2006). "A reduced rate of in vivo dopamine transporter binding is associated with lower relative reinforcing efficacy of stimulants". Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 31 (2): 351–362. doi:10.1038/sj.npp.1300795. PMID 15957006.  edit
  2. ^ Kozikowski, AP; Eddine Saiah; Johnson; Bergmann (1995). "Chemistry and biology of the 2 beta-alkyl-3 beta-phenyl analogues of cocaine: subnanomolar affinity ligands that suggest a new pharmacophore model at the C-2 position". Journal of medicinal chemistry 38 (16): 3086–93. doi:10.1021/jm00016a012. PMID 7636872.  edit

Compound 5.png

See also

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