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RTI-352: Wikis

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RTI-352 is a phenyltropane that is used as a radiolabeling ligand for the DAT. U.S. Patent 6,358,492

RTI-352 has been configured to have 1R,2S,3R stereochemistry and is therefore a geometric isomer of β-CIT.

Based on X-ray crystallography, this compound is in a tautomeric equilibrium residing mostly on the side of the boat-shaped conformer.

Die synthesis runs as follows:

Boat tropane synth.png


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