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Raclopride: Wikis


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Systematic (IUPAC) name
CAS number 84225-95-6
ATC code none
PubChem 3033769
Chemical data
Formula C 15H20Cl2N2O3  
Mol. mass 347.236 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 30 min
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Raclopride is a synthetic compound that acts as an antagonist on D2 dopamine receptors.[1] It can be radiolabelled with the carbon-11 radioisotope and used in positron emission tomography (PET) scanning to assess the degree of dopamine binding to the D2 neuroreceptor. For example, one study found decreasing binding with the personality trait detachment.[2]


  1. ^ C. Kohler, H. Hall, S. O. Ogren, L. Gawell (July 1985). "Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain". Biochemical Pharmacology 34 (13): 2251–2259. doi:10.1016/0006-2952(85)90778-6. PMID 4015674.  
  2. ^ Lars Farde, J. Petter Gustavsson, Erik Jönsson (February 1997). "D2 dopamine receptors and personality traits". Nature 385 (6617): 590. doi:10.1038/385590a0. PMID 9024656.  

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