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Ramatroban
File:Ramatroban.svg.
Systematic (IUPAC) name
3-((3R)-3-{[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9 H-carbazol-9-yl)propanoic acid
Identifiers
CAS number 116649-85-5
ATC code none
PubChem 123879
Chemical data
Formula C 21H21FN2O4S 
Mol. mass 416.46 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral

Ramatroban (INN) is a thromboxane receptor antagonist.[1]

It is also a CRTH2 antagonist.[2]

It is indicated for the treatment of coronary artery disease.[3] It has also been used for the treatment of asthma.[4]

It was developed by the German pharmaceutical company Bayer AG and is co-marketed in Japan by Bayer and Nippon Shinyaku Co. Ltd. under the tradename Baynas.

References

  1. ^ Sugimoto H, Shichijo M, Iino T, et al. (April 2003). "An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro". J. Pharmacol. Exp. Ther. 305 (1): 347–52. doi:10.1124/jpet.102.046748. PMID 12649388. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=12649388.  
  2. ^ Royer JF, Schratl P, Carrillo JJ, et al. (September 2008). "A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils". Eur. J. Clin. Invest. 38 (9): 663–71. doi:10.1111/j.1365-2362.2008.01989.x. PMID 18837743. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0014-2972&date=2008&volume=38&issue=9&spage=663.  
  3. ^ Fiedler VB, Seuter F, Perzborn E (December 1990). "Effects of the novel thromboxane antagonist Bay U 3405 on experimental coronary artery disease". Stroke 21 (12 Suppl): IV149–51. PMID 2260140.  
  4. ^ Endo S, Akiyama K (November 1996). "[Thromboxane A2 receptor antagonist in asthma therapy]" (in Japanese). Nippon Rinsho 54 (11): 3045–8. PMID 8950952.  

External links

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