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Updated live from Wikipedia, last check: May 14, 2013 18:45 UTC (41 seconds ago)

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Ranimustine
Systematic (IUPAC) name
methyl 6-({[(2-chloroethyl)(nitroso)amino]carbonyl}amino)-6-deoxy-α- D-glucopyranoside
Identifiers
CAS number 58994-96-0
ATC code L01AD07
PubChem 71741
Chemical data
Formula C 10H18ClN3O7  
Mol. mass 327.71 g/mol
SMILES eMolecules & PubChem
Synonyms 1-(2-chloroethyl)-1-nitroso-3-([(2R,3S,4 S,5R,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methyl)urea
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status ℞ Prescription only
Routes IV

Ranimustine (INN, marketed under the tradename Cymerin; also known as MCNU) is a nitrosourea alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia[1] and polycythemia vera.[2]

It has never been filed for FDA evaluation in the United States, where it is not marketed.

References

  1. ^ Kitajima K, Adachi T, Takahashi I, et al. (November 1989). "[Chemotherapy of chronic myelogenous leukemia--VP(M) regimen initiated during its chronic phase, and evaluation of MCNU in the phase of blastic crisis]" (in Japanese). Gan To Kagaku Ryoho 16 (11): 3573–9. PMID 2817908.  
  2. ^ Nagai M, Tasaka T, Kamano H, et al. (December 1988). "[Therapeutic effect of ranimustine (MCNU) on essential thrombocythemia and polycythemia vera]" (in Japanese). Gan To Kagaku Ryoho 15 (12): 3267–70. PMID 3196045.  







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