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Rauwolscine
Systematic (IUPAC) name
17α-hydroxy-20α-yohimban-16β-carboxylic acid methyl ester
Identifiers
CAS number 131-03-3 6211-32-1 (HCl)
ATC code none
PubChem 643606
ChemSpider 558737
Chemical data
Formula C21H26N2O3
Mol. mass 354.44 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Rauwolscine, also known as α-yohimbine and corynanthidine, is an alkaloid found in species of the Rauwolfia and Pausinystalia (formerly known as Corynanthe) genuses.[1] It is a stereoisomer of yohimbine.[1] Rauwolscine possess stimulant and aphrodisiac properties.[1]

Rauwolscine acts predominantly as a α2-adrenergic receptor antagonist.[2] It has also been shown to function as a 5-HT1A receptor partial agonist and 5-HT2A and 5-HT2B receptor antagonist.[3][4][5]

See also

References

  1. ^ a b c KOHLI JD, DE NN (June 1956). "Pharmacological action of rauwolscine". Nature 177 (4521): 1182. PMID 13334509. 
  2. ^ Perry BD, U'Prichard DC (December 1981). "[3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors". European Journal of Pharmacology 76 (4): 461–4. PMID 6276200. 
  3. ^ Arthur JM, Casañas SJ, Raymond JR (June 1993). "Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors". Biochemical Pharmacology 45 (11): 2337–41. PMID 8517875. 
  4. ^ Kaumann AJ (June 1983). "Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 323 (2): 149–54. PMID 6136920. 
  5. ^ Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL (January 1998). "[3HRauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor"]. Naunyn-Schmiedeberg's Archives of Pharmacology 357 (1): 17–24. PMID 9459568. http://link.springer.de/link/service/journals/00210/bibs/7357001/73570017.htm. 
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