The Full Wiki

More info on Rauwolscine

Rauwolscine: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
17α-hydroxy-20α-yohimban-16β-carboxylic acid methyl ester
CAS number 131-03-3 6211-32-1 (HCl)
ATC code none
PubChem 643606
ChemSpider 558737
Chemical data
Formula C21H26N2O3
Mol. mass 354.44 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Rauwolscine, also known as α-yohimbine and corynanthidine, is an alkaloid found in species of the Rauwolfia and Pausinystalia (formerly known as Corynanthe) genuses.[1] It is a stereoisomer of yohimbine.[1] Rauwolscine possess stimulant and aphrodisiac properties.[1]

Rauwolscine acts predominantly as a α2-adrenergic receptor antagonist.[2] It has also been shown to function as a 5-HT1A receptor partial agonist and 5-HT2A and 5-HT2B receptor antagonist.[3][4][5]

See also


  1. ^ a b c KOHLI JD, DE NN (June 1956). "Pharmacological action of rauwolscine". Nature 177 (4521): 1182. PMID 13334509. 
  2. ^ Perry BD, U'Prichard DC (December 1981). "[3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors". European Journal of Pharmacology 76 (4): 461–4. PMID 6276200. 
  3. ^ Arthur JM, Casañas SJ, Raymond JR (June 1993). "Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors". Biochemical Pharmacology 45 (11): 2337–41. PMID 8517875. 
  4. ^ Kaumann AJ (June 1983). "Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 323 (2): 149–54. PMID 6136920. 
  5. ^ Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL (January 1998). "[3HRauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor"]. Naunyn-Schmiedeberg's Archives of Pharmacology 357 (1): 17–24. PMID 9459568. 


Got something to say? Make a comment.
Your name
Your email address