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Relaxin/insulin-like family peptide receptor 4
Symbols RXFP4; GPCR142; GPR100; MGC126556; MGC126558; RLN3R2
External IDs OMIM609043 MGI2182926 HomoloGene18775 IUPHAR: RXFP4 GeneCards: RXFP4 Gene
Species Human Mouse
Entrez 339403 242093
Ensembl ENSG00000173080 ENSMUSG00000049741
UniProt Q8TDU9 Q3B805
RefSeq (mRNA) NM_181885 NM_181817
RefSeq (protein) NP_871001 NP_861538
Location (UCSC) Chr 1:
154.18 - 154.18 Mb
Chr 3:
88.74 - 88.74 Mb
PubMed search [1] [2]

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.[1]

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM][1]


See also


External links

Further reading

  • Bathgate RA, Ivell R, Sanborn BM, et al. (2005). "Receptors for relaxin family peptides.". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688.  
  • Bathgate RA, Ivell R, Sanborn BM, et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.  
  • Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Liu C, Chen J, Sutton S, et al. (2004). "Identification of relaxin-3/INSL7 as a ligand for GPCR142.". J. Biol. Chem. 278 (50): 50765–70. doi:10.1074/jbc.M308996200. PMID 14522967.  
  • Boels K, Schaller HC (2004). "Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor.". Br. J. Pharmacol. 140 (5): 932–8. doi:10.1038/sj.bjp.0705521. PMID 14530218.  
  • Fredriksson R, Höglund PJ, Gloriam DE, et al. (2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.". FEBS Lett. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098.  
  • Liu C, Chen J, Kuei C, et al. (2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.". Mol. Pharmacol. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Liu C, Kuei C, Sutton S, et al. (2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100).". J. Biol. Chem. 280 (1): 292–300. doi:10.1074/jbc.M409916200. PMID 15525639.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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