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Retinoblastoma-like protein 2: Wikis

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Retinoblastoma-like 2 (p130)
Identifiers
Symbols RBL2; FLJ26459; P130; Rb2
External IDs OMIM180203 MGI105085 HomoloGene4098 GeneCards: RBL2 Gene
RNA expression pattern
PBB GE RBL2 212331 at tn.png
PBB GE RBL2 212332 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5934 19651
Ensembl ENSG00000103479 ENSMUSG00000031666
UniProt Q08999 Q3TVP8
RefSeq (mRNA) NM_005611 NM_011250
RefSeq (protein) NP_005602 NP_035380
Location (UCSC) Chr 16:
52.03 - 52.08 Mb
Chr 8:
93.96 - 94.01 Mb
PubMed search [1] [2]

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.[1][2]

Contents

Interactions

Retinoblastoma-like protein 2 has been shown to interact with HDAC1,[3][4] C-Raf,[5] RBBP8,[6][7] Cyclin E1,[8][9] Prohibitin,[10] Cyclin-dependent kinase 2,[8][11] BRF1[12] and BRCA1.[13]

See also

Further reading

  • Soprano KJ, Purev E, Vuocolo S, Soprano DR (2006). "Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid.". Oncogene 25 (38): 5315–25. doi:10.1038/sj.onc.1209679. PMID 16936753.  
  • De Falco G, Giordano A (2006). "pRb2/p130: a new candidate for retinoblastoma tumor formation.". Oncogene 25 (38): 5333–40. doi:10.1038/sj.onc.1209614. PMID 16936755.  
  • Hijmans EM, Voorhoeve PM, Beijersbergen RL, et al. (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo.". Mol. Cell. Biol. 15 (6): 3082–9. PMID 7760804.  
  • Sardet C, Vidal M, Cobrinik D, et al. (1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMID 7892279.  
  • Yeung RS, Bell DW, Testa JR, et al. (1993). "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19.". Oncogene 8 (12): 3465–8. PMID 8247552.  
  • Li Y, Graham C, Lacy S, et al. (1994). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.". Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.  
  • Hannon GJ, Demetrick D, Beach D (1994). "Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.". Genes Dev. 7 (12A): 2378–91. doi:10.1101/gad.7.12a.2378. PMID 8253384.  
  • Lavender P, Vandel L, Bannister AJ, Kouzarides T (1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A.". Oncogene 14 (22): 2721–8. doi:10.1038/sj.onc.1201243. PMID 9178770.  
  • Lacy S, Whyte P (1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes.". Oncogene 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. PMID 9188854.  
  • Shao Z, Siegert JL, Ruppert S, Robbins PD (1997). "Rb interacts with TAF(II)250/TFIID through multiple domains.". Oncogene 15 (4): 385–92. doi:10.1038/sj.onc.1201204. PMID 9242374.  
  • Sterner JM, Dew-Knight S, Musahl C, et al. (1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.". Mol. Cell. Biol. 18 (5): 2748–57. PMID 9566894.  
  • Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.". Nat. Genet. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699.  
  • Veal E, Eisenstein M, Tseng ZH, Gill G (1998). "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.". Mol. Cell. Biol. 18 (9): 5032–41. PMID 9710587.  
  • Fusco C, Reymond A, Zervos AS (1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein.". Genomics 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.  
  • Ferreira R, Magnaghi-Jaulin L, Robin P, et al. (1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10493–8. doi:10.1073/pnas.95.18.10493. PMID 9724731.  
  • Paramio JM, Laín S, Segrelles C, et al. (1998). "Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation.". Oncogene 17 (8): 949–57. doi:10.1038/sj.onc.1202031. PMID 9747874.  
  • Wang S, Ghosh RN, Chellappan SP (1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation.". Mol. Cell. Biol. 18 (12): 7487–98. PMID 9819434.  
  • Yang R, Müller C, Huynh V, et al. (1999). "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.". Mol. Cell. Biol. 19 (3): 2400–7. PMID 10022926.  

References

  1. ^ Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (Sep 1993). "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene 8 (9): 2561–6. PMID 8361765.  
  2. ^ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (Jul 1996). "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proc Natl Acad Sci U S A 93 (10): 4629–32. PMID 8643454.  
  3. ^ Ferreira, R; Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep. 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493–8. ISSN 0027-8424. PMID 9724731.  
  4. ^ Bouzahzah, B; Fu M, Iavarone A, Factor V M, Thorgeirsson S S, Pestell R G (Aug. 2000). "Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo". Cancer Res. (UNITED STATES) 60 (16): 4531–7. ISSN 0008-5472. PMID 10969803.  
  5. ^ Wang, S; Ghosh R N, Chellappan S P (Dec. 1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487–98. ISSN 0270-7306. PMID 9819434.  
  6. ^ Meloni, A R; Smith E J, Nevins J R (Aug. 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574–9. ISSN 0027-8424. PMID 10449734.  
  7. ^ Fusco, C; Reymond A, Zervos A S (Aug. 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics (UNITED STATES) 51 (3): 351–8. doi:10.1006/geno.1998.5368. ISSN 0888-7543. PMID 9721205.  
  8. ^ a b Shanahan, F; Seghezzi W, Parry D, Mahony D, Lees E (Feb. 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460–9. ISSN 0270-7306. PMID 9891079.  
  9. ^ Li, Y; Graham C, Lacy S, Duncan A M, Whyte P (Dec. 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. (UNITED STATES) 7 (12A): 2366–77. ISSN 0890-9369. PMID 8253383.  
  10. ^ Wang, S; Nath N, Adlam M, Chellappan S (Jun. 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene (ENGLAND) 18 (23): 3501–10. doi:10.1038/sj.onc.1202684. ISSN 0950-9232. PMID 10376528.  
  11. ^ Lacy, S; Whyte P (May. 1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene (ENGLAND) 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. ISSN 0950-9232. PMID 9188854.  
  12. ^ Sutcliffe, J E; Cairns C A, McLees A, Allison S J, Tosh K, White R J (Jun. 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255–61. ISSN 0270-7306. PMID 10330166.  
  13. ^ Fan, S; Yuan R, Ma Y X, Xiong J, Meng Q, Erdos M, Zhao J N, Goldberg I D, Pestell R G, Rosen E M (Aug. 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene (England) 20 (35): 4827–41. doi:10.1038/sj.onc.1204666. ISSN 0950-9232. PMID 11521194.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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