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Retinoic acid-inducible orphan G protein-coupled receptor: Wikis


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G protein-coupled receptor, family C, group 5, member A
Symbol GPRC5A
Alt. symbols RAIG1, RAI3
Entrez 9052
HUGO 9836
OMIM 604138
RefSeq NM_003979
UniProt Q8NFJ5
Other data
Locus Chr. 12 p13-p12.3
G protein coupled receptor, family C, group 5, member B
Symbol GPRC5B
Alt. symbols RAIG2
Entrez 51704
HUGO 13308
OMIM 605948
RefSeq NM_016235
UniProt Q9NZH0
Other data
Locus Chr. 16 p12
G protein-coupled receptor, family C, group 5, member C
Symbol GPRC5C
Alt. symbols RAIG3
Entrez 55890
HUGO 13309
OMIM 605949
RefSeq NM_022036
UniProt Q9NQ84
Other data
Locus Chr. 17 q25
G protein-coupled receptor, family C, group 5, member D
Symbol GPRC5D
Entrez 55507
HUGO 13310
OMIM 607437
RefSeq NM_018654
UniProt Q9NZD1
Other data
Locus Chr. 12 p13.3

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.[1][2][3][4]

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.[5]


  1. ^ Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.  
  2. ^ Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.  
  3. ^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.  
  4. ^ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta 1518 (3): 237–48. PMID 11311935.  
  5. ^ Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic acid-inducible G protein-coupled receptors bind to frizzled receptors and may activate non-canonical Wnt signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMID 17521608.  

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