The Full Wiki

More info on Retinoic acid-inducible orphan G protein-coupled receptor

Retinoic acid-inducible orphan G protein-coupled receptor: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

G protein-coupled receptor, family C, group 5, member A
Identifiers
Symbol GPRC5A
Alt. symbols RAIG1, RAI3
Entrez 9052
HUGO 9836
OMIM 604138
RefSeq NM_003979
UniProt Q8NFJ5
Other data
Locus Chr. 12 p13-p12.3
G protein coupled receptor, family C, group 5, member B
Identifiers
Symbol GPRC5B
Alt. symbols RAIG2
Entrez 51704
HUGO 13308
OMIM 605948
RefSeq NM_016235
UniProt Q9NZH0
Other data
Locus Chr. 16 p12
G protein-coupled receptor, family C, group 5, member C
Identifiers
Symbol GPRC5C
Alt. symbols RAIG3
Entrez 55890
HUGO 13309
OMIM 605949
RefSeq NM_022036
UniProt Q9NQ84
Other data
Locus Chr. 17 q25
G protein-coupled receptor, family C, group 5, member D
Identifiers
Symbol GPRC5D
Entrez 55507
HUGO 13310
OMIM 607437
RefSeq NM_018654
UniProt Q9NZD1
Other data
Locus Chr. 12 p13.3

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.[1][2][3][4]

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.[5]

References

  1. ^ Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.  
  2. ^ Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.  
  3. ^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.  
  4. ^ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta 1518 (3): 237–48. PMID 11311935.  
  5. ^ Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic acid-inducible G protein-coupled receptors bind to frizzled receptors and may activate non-canonical Wnt signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMID 17521608.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message