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Retinoic acid receptor alpha: Wikis


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Retinoic acid receptor, alpha

PDB rendering based on 1dkf.
Available structures
1dkf, 1dsz, 1hra
Symbols RARA; NR1B1; RAR
External IDs OMIM180240 MGI97856 HomoloGene20262 GeneCards: RARA Gene
RNA expression pattern
PBB GE RARA 203749 s at tn.png
PBB GE RARA 203750 s at tn.png
PBB GE RARA 211605 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5914 19401
Ensembl ENSG00000131759 ENSMUSG00000037992
UniProt P10276 Q3U3R3
RefSeq (mRNA) NM_001033603 NM_009024
RefSeq (protein) NP_001028775 NP_033050
Location (UCSC) Chr 17:
35.72 - 35.77 Mb
Chr 11:
98.75 - 98.79 Mb
PubMed search [1] [2]

Retinoic acid receptor alpha (RAR-alpha), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor encoded by the RARA gene.



Retinoic acid receptor alpha has been shown to interact with NCOA6,[1][2][3] CLOCK,[4] TADA3L,[5] Zinc finger and BTB domain-containing protein 16,[6] Src,[7][8] Nuclear receptor related 1 protein,[9] Small heterodimer partner,[10][11] NPAS2,[4] Cyclin D3,[12] Nuclear receptor co-repressor 1,[13][14] BAG1,[15] Nuclear receptor co-repressor 2,[16][17] NRIP1,[18][19][20] Promyelocytic leukemia protein[21] and Retinoid X receptor alpha.[22][23]

See also

Further reading

  • Petkovich M, Brand NJ, Krust A, Chambon P (1988). "A human retinoic acid receptor which belongs to the family of nuclear receptors.". Nature 330 (6147): 444–50. doi:10.1038/330444a0. PMID 2825025.  
  • Sirulnik A, Melnick A, Zelent A, Licht JD (2004). "Molecular pathogenesis of acute promyelocytic leukaemia and APL variants.". Best practice & research. Clinical haematology 16 (3): 387–408. doi:10.1016/S1521-6926(03)00062-8. PMID 12935958.  
  • Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM (1992). "Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.". Nature 355 (6359): 446–9. doi:10.1038/355446a0. PMID 1310351.  
  • Kastner P, Perez A, Lutz Y, et al. (1992). "Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.". Embo J. 11 (2): 629–42. PMID 1311253.  
  • Baniahmad A, Köhne AC, Renkawitz R (1992). "A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.". Embo J. 11 (3): 1015–23. PMID 1347744.  
  • de Thé H, Lavau C, Marchio A, et al. (1991). "The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.". Cell 66 (4): 675–84. doi:10.1016/0092-8674(91)90113-D. PMID 1652369.  
  • de Thé H, Chomienne C, Lanotte M, et al. (1990). "The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.". Nature 347 (6293): 558–61. doi:10.1038/347558a0. PMID 2170850.  
  • Brand NJ, Petkovich M, Chambon P (1991). "Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha).". Nucleic Acids Res. 18 (23): 6799–806. doi:10.1093/nar/18.23.6799. PMID 2175878.  
  • Borrow J, Goddard AD, Sheer D, Solomon E (1990). "Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.". Science 249 (4976): 1577–80. doi:10.1126/science.2218500. PMID 2218500.  
  • Giguere V, Ong ES, Segui P, Evans RM (1988). "Identification of a receptor for the morphogen retinoic acid.". Nature 330 (6149): 624–9. doi:10.1038/330624a0. PMID 2825036.  
  • Arveiler B, Petkovich M, Mandel JL, Chambon P (1988). "A PstI RFLP for the human retinoic acid receptor in 17q21.". Nucleic Acids Res. 16 (13): 6252. doi:10.1093/nar/16.13.6252. PMID 2899875.  
  • Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors.". Nature 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127.  
  • Fisher GJ, Talwar HS, Xiao JH, et al. (1994). "Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin.". J. Biol. Chem. 269 (32): 20629–35. PMID 8051161.  
  • Anderson LA, Friedman L, Osborne-Lawrence S, et al. (1993). "High-density genetic map of the BRCA1 region of chromosome 17q12-q21.". Genomics 17 (3): 618–23. doi:10.1006/geno.1993.1381. PMID 8244378.  
  • Chen Z, Guidez F, Rousselot P, et al. (1994). "PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1178–82. doi:10.1073/pnas.91.3.1178. PMID 8302850.  
  • Redner RL, Rush EA, Faas S, et al. (1996). "The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.". Blood 87 (3): 882–6. PMID 8562957.  
  • Kamei Y, Xu L, Heinzel T, et al. (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.". Cell 85 (3): 403–14. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895.  
  • Liu W, Hellman P, Li Q, et al. (1997). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.". Biochem. Biophys. Res. Commun. 229 (3): 922–9. doi:10.1006/bbrc.1996.1903. PMID 9005841.  
  • Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.". J. Biol. Chem. 272 (18): 12062–8. doi:10.1074/jbc.272.18.12062. PMID 9115274.  


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