The Full Wiki

Retinoic acid receptor alpha: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Retinoic acid receptor, alpha

PDB rendering based on 1dkf.
Available structures
1dkf, 1dsz, 1hra
Identifiers
Symbols RARA; NR1B1; RAR
External IDs OMIM180240 MGI97856 HomoloGene20262 GeneCards: RARA Gene
RNA expression pattern
PBB GE RARA 203749 s at tn.png
PBB GE RARA 203750 s at tn.png
PBB GE RARA 211605 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5914 19401
Ensembl ENSG00000131759 ENSMUSG00000037992
UniProt P10276 Q3U3R3
RefSeq (mRNA) NM_001033603 NM_009024
RefSeq (protein) NP_001028775 NP_033050
Location (UCSC) Chr 17:
35.72 - 35.77 Mb
Chr 11:
98.75 - 98.79 Mb
PubMed search [1] [2]

Retinoic acid receptor alpha (RAR-alpha), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a nuclear receptor encoded by the RARA gene.

Contents

Interactions

Retinoic acid receptor alpha has been shown to interact with NCOA6,[1][2][3] CLOCK,[4] TADA3L,[5] Zinc finger and BTB domain-containing protein 16,[6] Src,[7][8] Nuclear receptor related 1 protein,[9] Small heterodimer partner,[10][11] NPAS2,[4] Cyclin D3,[12] Nuclear receptor co-repressor 1,[13][14] BAG1,[15] Nuclear receptor co-repressor 2,[16][17] NRIP1,[18][19][20] Promyelocytic leukemia protein[21] and Retinoid X receptor alpha.[22][23]

See also

Further reading

  • Petkovich M, Brand NJ, Krust A, Chambon P (1988). "A human retinoic acid receptor which belongs to the family of nuclear receptors.". Nature 330 (6147): 444–50. doi:10.1038/330444a0. PMID 2825025.  
  • Sirulnik A, Melnick A, Zelent A, Licht JD (2004). "Molecular pathogenesis of acute promyelocytic leukaemia and APL variants.". Best practice & research. Clinical haematology 16 (3): 387–408. doi:10.1016/S1521-6926(03)00062-8. PMID 12935958.  
  • Kliewer SA, Umesono K, Mangelsdorf DJ, Evans RM (1992). "Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.". Nature 355 (6359): 446–9. doi:10.1038/355446a0. PMID 1310351.  
  • Kastner P, Perez A, Lutz Y, et al. (1992). "Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.". Embo J. 11 (2): 629–42. PMID 1311253.  
  • Baniahmad A, Köhne AC, Renkawitz R (1992). "A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.". Embo J. 11 (3): 1015–23. PMID 1347744.  
  • de Thé H, Lavau C, Marchio A, et al. (1991). "The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.". Cell 66 (4): 675–84. doi:10.1016/0092-8674(91)90113-D. PMID 1652369.  
  • de Thé H, Chomienne C, Lanotte M, et al. (1990). "The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.". Nature 347 (6293): 558–61. doi:10.1038/347558a0. PMID 2170850.  
  • Brand NJ, Petkovich M, Chambon P (1991). "Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha).". Nucleic Acids Res. 18 (23): 6799–806. doi:10.1093/nar/18.23.6799. PMID 2175878.  
  • Borrow J, Goddard AD, Sheer D, Solomon E (1990). "Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.". Science 249 (4976): 1577–80. doi:10.1126/science.2218500. PMID 2218500.  
  • Giguere V, Ong ES, Segui P, Evans RM (1988). "Identification of a receptor for the morphogen retinoic acid.". Nature 330 (6149): 624–9. doi:10.1038/330624a0. PMID 2825036.  
  • Arveiler B, Petkovich M, Mandel JL, Chambon P (1988). "A PstI RFLP for the human retinoic acid receptor in 17q21.". Nucleic Acids Res. 16 (13): 6252. doi:10.1093/nar/16.13.6252. PMID 2899875.  
  • Chen JD, Evans RM (1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors.". Nature 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127.  
  • Fisher GJ, Talwar HS, Xiao JH, et al. (1994). "Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin.". J. Biol. Chem. 269 (32): 20629–35. PMID 8051161.  
  • Anderson LA, Friedman L, Osborne-Lawrence S, et al. (1993). "High-density genetic map of the BRCA1 region of chromosome 17q12-q21.". Genomics 17 (3): 618–23. doi:10.1006/geno.1993.1381. PMID 8244378.  
  • Chen Z, Guidez F, Rousselot P, et al. (1994). "PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1178–82. doi:10.1073/pnas.91.3.1178. PMID 8302850.  
  • Redner RL, Rush EA, Faas S, et al. (1996). "The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.". Blood 87 (3): 882–6. PMID 8562957.  
  • Kamei Y, Xu L, Heinzel T, et al. (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.". Cell 85 (3): 403–14. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895.  
  • Liu W, Hellman P, Li Q, et al. (1997). "Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.". Biochem. Biophys. Res. Commun. 229 (3): 922–9. doi:10.1006/bbrc.1996.1903. PMID 9005841.  
  • Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.". J. Biol. Chem. 272 (18): 12062–8. doi:10.1074/jbc.272.18.12062. PMID 9115274.  

References

  1. ^ Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (Feb. 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. (United States) 15 (2): 241–54. ISSN 0888-8809. PMID 11158331.  
  2. ^ Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. ISSN 0021-9258. PMID 10567404.  
  3. ^ Ko, L; Cardona G R, Chin W W (May. 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (11): 6212–7. ISSN 0027-8424. PMID 10823961.  
  4. ^ a b McNamara, P; Seo S B, Rudic R D, Sehgal A, Chakravarti D, FitzGerald G A (Jun. 2001). "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock". Cell (United States) 105 (7): 877–89. ISSN 0092-8674. PMID 11439184.  
  5. ^ Zeng, Musheng; Kumar Ajay, Meng Gaoyuan, Gao Qingshen, Dimri Goberdhan, Wazer David, Band Hamid, Band Vimla (Nov. 2002). "Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator". J. Biol. Chem. (United States) 277 (47): 45611–8. doi:10.1074/jbc.M208447200. ISSN 0021-9258. PMID 12235159.  
  6. ^ Martin; Delmotte , Formstecher , Lefebvre (Sep. 2003). "PLZF is a negative regulator of retinoic acid receptor transcriptional activity". Nucl. Recept. 1 (1): 6. doi:10.1186/1478-1336-1-6. PMID 14521715.  
  7. ^ Kim, H J; Yi J Y, Sung H S, Moore D D, Jhun B H, Lee Y C, Lee J W (Sep. 1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Mol. Cell. Biol. (UNITED STATES) 19 (9): 6323–32. ISSN 0270-7306. PMID 10454579.  
  8. ^ He, Bin; Wilson Elizabeth M (Mar. 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. (United States) 23 (6): 2135–50. ISSN 0270-7306. PMID 12612084.  
  9. ^ Perlmann, T; Jansson L (Apr. 1995). "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1". Genes Dev. (UNITED STATES) 9 (7): 769–82. ISSN 0890-9369. PMID 7705655.  
  10. ^ Seol, W; Choi H S, Moore D D (May. 1996). "An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors". Science (UNITED STATES) 272 (5266): 1336–9. ISSN 0036-8075. PMID 8650544.  
  11. ^ Seol, W; Hanstein B, Brown M, Moore D D (Oct. 1998). "Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)". Mol. Endocrinol. (UNITED STATES) 12 (10): 1551–7. ISSN 0888-8809. PMID 9773978.  
  12. ^ Despouy, Gilles; Bastie Jean-Nöel, Deshaies Sylvie, Balitrand Nicole, Mazharian Alexandra, Rochette-Egly Cécile, Chomienne Christine, Delva Laurent (Feb. 2003). "Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II". J. Biol. Chem. (United States) 278 (8): 6355–62. doi:10.1074/jbc.M210697200. ISSN 0021-9258. PMID 12482873.  
  13. ^ Dowell, P; Ishmael J E, Avram D, Peterson V J, Nevrivy D J, Leid M (May. 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". J. Biol. Chem. (UNITED STATES) 274 (22): 15901–7. ISSN 0021-9258. PMID 10336495.  
  14. ^ Guidez, F; Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (Apr. 1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood (UNITED STATES) 91 (8): 2634–42. ISSN 0006-4971. PMID 9531570.  
  15. ^ Liu, R; Takayama S, Zheng Y, Froesch B, Chen G Q, Zhang X, Reed J C, Zhang X K (Jul. 1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells". J. Biol. Chem. (UNITED STATES) 273 (27): 16985–92. ISSN 0021-9258. PMID 9642262.  
  16. ^ Dong, Shuo; Tweardy David J (Apr. 2002). "Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways". Blood (United States) 99 (8): 2637–46. ISSN 0006-4971. PMID 11929748.  
  17. ^ Hong, S H; David G, Wong C W, Dejean A, Privalsky M L (Aug. 1997). "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (17): 9028–33. ISSN 0027-8424. PMID 9256429.  
  18. ^ Hu, Xinli; Chen Yixin, Farooqui Mariya, Thomas Mary C, Chiang Cheng-Ming, Wei Li-Na (Jan. 2004). "Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation". J. Biol. Chem. (United States) 279 (1): 319–25. doi:10.1074/jbc.M307621200. ISSN 0021-9258. PMID 14581481.  
  19. ^ Farooqui, Mariya; Franco Peter J, Thompson Jim, Kagechika Hiroyuki, Chandraratna Roshantha A S, Banaszak Len, Wei Li-Na (Feb. 2003). "Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity". Biochemistry (United States) 42 (4): 971–9. doi:10.1021/bi020497k. ISSN 0006-2960. PMID 12549917.  
  20. ^ L'Horset, F; Dauvois S, Heery D M, Cavaillès V, Parker M G (Nov. 1996). "RIP-140 interacts with multiple nuclear receptors by means of two distinct sites". Mol. Cell. Biol. (UNITED STATES) 16 (11): 6029–36. ISSN 0270-7306. PMID 8887632.  
  21. ^ Zhong, S; Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman L P, Pandolfi P P (Nov. 1999). "A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins". Nat. Genet. (UNITED STATES) 23 (3): 287–95. doi:10.1038/15463. ISSN 1061-4036. PMID 10610177.  
  22. ^ Benkoussa, Madjid; Brand Céline, Delmotte Marie-Hélène, Formstecher Pierre, Lefebvre Philippe (Jul. 2002). "Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter". Mol. Cell. Biol. (United States) 22 (13): 4522–34. ISSN 0270-7306. PMID 12052862.  
  23. ^ Bugge, T H; Pohl J, Lonnoy O, Stunnenberg H G (Apr. 1992). "RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors". EMBO J. (ENGLAND) 11 (4): 1409–18. ISSN 0261-4189. PMID 1314167.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message