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Retinoic acid receptor gamma: Wikis


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Retinoic acid receptor, gamma

PDB rendering based on 1dsz.
Available structures
1dsz, 1exa, 1exx, 1fcx, 1fcy, 1fcz, 1fd0, 1hra, 2lbd, 3lbd, 4lbd
Symbols RARG; NR1B3; RARC
External IDs OMIM180190 MGI97858 HomoloGene20263 GeneCards: RARG Gene
Species Human Mouse
Entrez 5916 19411
Ensembl n/a ENSMUSG00000001288
UniProt n/a Q3UG86
RefSeq (mRNA) XM_940838 NM_001042727
RefSeq (protein) XP_945931 NP_001036192
Location (UCSC) n/a Chr 15:
102.06 - 102.09 Mb
PubMed search [1] [2]

Retinoic acid receptor gamma (RAR-gamma), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.[1]



Retinoic acid receptor gamma has been shown to interact with Nuclear receptor co-repressor 1.[2]

See also


  1. ^ "Entrez Gene: RARG retinoic acid receptor, gamma".  
  2. ^ Dowell, P; Ishmael J E, Avram D, Peterson V J, Nevrivy D J, Leid M (May. 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". J. Biol. Chem. (UNITED STATES) 274 (22): 15901–7. ISSN 0021-9258. PMID 10336495.  

Further reading

  • Leid M, Kastner P, Lyons R, et al. (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.". Cell 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259.  
  • Vollberg TM, Nervi C, George MD, et al. (1992). "Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation.". Mol. Endocrinol. 6 (5): 667–76. doi:10.1210/me.6.5.667. PMID 1318502.  
  • Lehmann JM, Zhang XK, Pfahl M (1992). "RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites.". Mol. Cell. Biol. 12 (7): 2976–85. PMID 1320193.  
  • Mattei MG, Rivière M, Krust A, et al. (1991). "Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes.". Genomics 10 (4): 1061–9. doi:10.1016/0888-7543(91)90199-O. PMID 1655630.  
  • Lehmann JM, Hoffmann B, Pfahl M (1991). "Genomic organization of the retinoic acid receptor gamma gene.". Nucleic Acids Res. 19 (3): 573–8. doi:10.1093/nar/19.3.573. PMID 1849262.  
  • Kastner P, Krust A, Mendelsohn C, et al. (1990). "Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2700–4. doi:10.1073/pnas.87.7.2700. PMID 2157210.  
  • Giguère V, Shago M, Zirngibl R, et al. (1990). "Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo.". Mol. Cell. Biol. 10 (5): 2335–40. PMID 2157970.  
  • Ishikawa T, Umesono K, Mangelsdorf DJ, et al. (1990). "A functional retinoic acid receptor encoded by the gene on human chromosome 12.". Mol. Endocrinol. 4 (6): 837–44. doi:10.1210/mend-4-6-837. PMID 2172793.  
  • Krust A, Kastner P, Petkovich M, et al. (1989). "A third human retinoic acid receptor, hRAR-gamma.". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5310–4. doi:10.1073/pnas.86.14.5310. PMID 2546152.  
  • Renaud JP, Rochel N, Ruff M, et al. (1996). "Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.". Nature 378 (6558): 681–9. doi:10.1038/378681a0. PMID 7501014.  
  • Zhou L, Pang J, Munroe DG, Lau C (1993). "A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7.". Nucleic Acids Res. 21 (10): 2520. doi:10.1093/nar/21.10.2520. PMID 7685085.  
  • Zitnik RJ, Kotloff RM, Latifpour J, et al. (1994). "Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts.". J. Immunol. 152 (3): 1419–27. PMID 8301142.  
  • Botling J, Castro DS, Oberg F, et al. (1997). "Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation.". J. Biol. Chem. 272 (14): 9443–9. doi:10.1074/jbc.272.14.9443. PMID 9083083.  
  • Lømo J, Smeland EB, Ulven S, et al. (1998). "RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes.". J. Cell. Physiol. 175 (1): 68–77. doi:10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A. PMID 9491782.  
  • Klaholz BP, Renaud JP, Mitschler A, et al. (1998). "Conformational adaptation of agonists to the human nuclear receptor RAR gamma.". Nat. Struct. Biol. 5 (3): 199–202. doi:10.1038/nsb0398-199. PMID 9501913.  
  • Zhang ZP, Gambone CJ, Gabriel JL, et al. (1999). "Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma.". J. Biol. Chem. 273 (51): 34016–21. doi:10.1074/jbc.273.51.34016. PMID 9852056.  
  • Yang C, Zhou D, Chen S (1999). "Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor.". Cancer Res. 58 (24): 5695–700. PMID 9865725.  
  • Nagpal S, Ghosn C, DiSepio D, et al. (1999). "Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor.". J. Biol. Chem. 274 (32): 22563–8. doi:10.1074/jbc.274.32.22563. PMID 10428834.  
  • Egea PF, Mitschler A, Rochel N, et al. (2000). "Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid.". EMBO J. 19 (11): 2592–601. doi:10.1093/emboj/19.11.2592. PMID 10835357.  
  • Boudjelal M, Voorhees JJ, Fisher GJ (2002). "Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells.". Exp. Cell Res. 274 (1): 130–7. doi:10.1006/excr.2001.5450. PMID 11855864.  


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