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Retinoid X receptor gamma: Wikis


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From Wikipedia, the free encyclopedia

Retinoid X receptor, gamma

Crystallographic structure of the DNA-binding domain of the Retinoid X receptor, gamma. PDB rendering based on 1by4.
Available structures
1by4, 1dsz, 1r0n, 1rxr, 2gl8, 2nll
Symbols RXRG; NR2B3; RXRC
External IDs OMIM180247 MGI98216 HomoloGene21373 GeneCards: RXRG Gene
RNA expression pattern
PBB GE RXRG 205954 at tn.png
More reference expression data
Species Human Mouse
Entrez 6258 20183
Ensembl ENSG00000143171 ENSMUSG00000015843
UniProt P48443 Q3V193
RefSeq (mRNA) NM_001009598 NM_009107
RefSeq (protein) NP_001009598 NP_033133
Location (UCSC) Chr 1:
163.64 - 163.68 Mb
Chr 1:
169.44 - 169.48 Mb
PubMed search [1] [2]

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor encoded by the RXRG gene.[1]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]


See also


Retinoid X receptor gamma has been shown to interact with ITGB3BP.[2]


  1. ^ a b "Entrez Gene: RXRG retinoid X receptor, gamma".  
  2. ^ Li, D; Wang F, Samuels H H (Dec. 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. (United States) 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. ISSN 0270-7306. PMID 11713274.  

Further reading

  • Szanto A, Narkar V, Shen Q, et al. (2005). "Retinoid X receptors: X-ploring their (patho)physiological functions.". Cell Death Differ. 11 Suppl 2: S126–43. doi:10.1038/sj.cdd.4401533. PMID 15608692.  
  • Leid M, Kastner P, Lyons R, et al. (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.". Cell 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259.  
  • Mangelsdorf DJ, Borgmeyer U, Heyman RA, et al. (1992). "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.". Genes Dev. 6 (3): 329–44. doi:10.1101/gad.6.3.329. PMID 1312497.  
  • Nagata T, Weiss EH, Abe K, et al. (1995). "Physical mapping of the retinoid X receptor B gene in mouse and human.". Immunogenetics 41 (2-3): 83–90. doi:10.1007/BF00182317. PMID 7806300.  
  • Almasan A, Mangelsdorf DJ, Ong ES, et al. (1994). "Chromosomal localization of the human retinoid X receptors.". Genomics 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.  
  • Muscat GE, Mynett-Johnson L, Dowhan D, et al. (1994). "Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors.". Nucleic Acids Res. 22 (4): 583–91. doi:10.1093/nar/22.4.583. PMID 8127707.  
  • Kamei Y, Xu L, Heinzel T, et al. (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.". Cell 85 (3): 403–14. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Sanno N, Sugawara A, Teramoto A, et al. (1997). "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas.". Neuroendocrinology 65 (4): 299–306. doi:10.1159/000127188. PMID 9143002.  
  • Reichrath J, Mittmann M, Kamradt J, Müller SM (1997). "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation.". Histochem. J. 29 (2): 127–33. doi:10.1023/A:1026481205135. PMID 9147069.  
  • Xu XC, Sozzi G, Lee JS, et al. (1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development.". J. Natl. Cancer Inst. 89 (9): 624–9. doi:10.1093/jnci/89.9.624. PMID 9150186.  
  • Yusta B, Alarid ET, Gordon DF, et al. (1998). "The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells.". Endocrinology 139 (11): 4476–82. doi:10.1210/en.139.11.4476. PMID 9794455.  
  • Ito K, Suzuki T, Moriya T, et al. (2001). "Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase.". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. doi:10.1210/jc.86.6.2721. PMID 11397877.  
  • Kim SW, Kim HJ, Jung DJ, et al. (2001). "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins.". Oncogene 20 (45): 6638–42. doi:10.1038/sj.onc.1204695. PMID 11641790.  
  • Brabender J, Danenberg KD, Metzger R, et al. (2002). "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.". Clin. Cancer Res. 8 (2): 438–43. PMID 11839661.  
  • Wansa KD, Harris JM, Muscat GE (2002). "The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment.". J. Biol. Chem. 277 (36): 33001–11. doi:10.1074/jbc.M203572200. PMID 12082103.  
  • Wang Q, Fujii H, Knipp GT (2003). "Expression of PPAR and RXR isoforms in the developing rat and human term placentas.". Placenta 23 (8-9): 661–71. doi:10.1053/plac.2002.0855. PMID 12361685.  
  • Kimura Y, Suzuki T, Kaneko C, et al. (2003). "Retinoid receptors in the developing human lung.". Clin. Sci. 103 (6): 613–21. doi:10.1042/. PMID 12444914.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Alfaro JM, Fraile B, Lobo MV, et al. (2003). "Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.". J. Androl. 24 (1): 113–9. PMID 12514092.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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