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Transcription factors and intracellular
receptors |
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(1) Basic
domains |
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Activating transcription
factor ( AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1
( c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) · BACH ( 1, 2) ·
BATF · BLZF1 · C/EBP ( α, β, γ, δ, ε, ζ) · CREB ( 1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF ( B, F, G, K) · NFE ( 2, L1, L2) · NFIL3 · NRL · NRF1 ·
XBP1
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(1.2) Basic
helix-loop-helix ( bHLH)
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ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL ( ARNTL, ARNTL2) · CLOCK · EPAS1 · HAND ( 1, 2) ·
HES ( 5, 6) ·
HEY ( 1, 2, L) · HES1 ·
HIF ( 1A, 3A) ·
ID ( 1, 2, 3,
4) · LYL1 ·
MXD4 · MYCL1 · MYCN · Myogenic regulatory factors
( MyoD, Myogenin, MYF5, MYF6) · Neurogenins · NeuroD ( 1, 2) · NPAS ( 1, 2, 3) · OLIG ( 1, 2) ·
Pho4 · Scleraxis · TAL ( 1, 2) ·
Twist · USF1
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(1.4) NF-1
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(1.5) RF-X
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(1.6) Basic helix-span-helix
(bHSH)
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(2) Zinc finger DNA-binding
domains |
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subfamily 1 ( Thyroid hormone ( α, β), CAR, FXR,
LXR ( α, β),
PPAR ( α, β/δ,
γ), PXR, RAR ( α, β, γ), ROR ( α, β, γ), Rev-ErbA ( α, β), VDR)
subfamily 2 ( COUP-TF
( I, II), Ear-2, HNF4 ( α, γ), PNR, RXR ( α, β, γ), Testicular
receptor ( 2, 4),
TLX)
subfamily 3 ( Steroid hormone ( Androgen,
Estrogen
( α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related ( α, β, γ))
subfamily 4 NUR ( NGFIB, NOR1, NURR1) · subfamily 5 ( LRH-1, SF1) · subfamily 6 ( GCNF) · subfamily 0 ( DAX1, SHP)
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(2.2) Other
Cys4
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(2.3)
Cys2His2
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General transcription
factors ( TFIIA, TFIIB, TFIID, TFIIE, TFIIF ( 1, 2), TFIIH ( 1, 2, 4, 2I, 3A, 3C1, 3C2))
ATBF1 · BCL ( 6, 11A, 11B) · CTCF ·
E4F1 · EGR ( 2, 3) ·
ERV3 · GFI1 ·
GLI-Krüppel family ( 1, 2, 3, REST, S2, YY1) ·
HIC ( 1, 2) ·
HIVEP ( 1, 2, 3) ·
IKZF ( 1, 2, 3) ·
ILF ( 2, 3) ·
KLF ( 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17) ·
MTF1 · MYT1 ·
OSR1 · SP ( 1, 2, 4, 7) · Zbtb7 ( 7A,
7B) · ZBTB ( 16, 17, 20, 32, 33, 40) · zinc finger ( 3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148,
165, 202, 217,
219, 238, 239,
259, 267, 268,
281, 295, 318,
330, 346, 350,
365, 366, 384,
423, 451, 452,
471, 593, 638,
649, 655)
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(2.4)
Cys6
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(2.5) Alternating
composition
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(3) Helix-turn-helix
domains |
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ARX · CDX ( 1, 2) ·
CRX · CUTL1 · DLX ( 3, 4, 5) · EMX2 ·
EN ( 1, 2) · FHL ( 1, 2, 3) · HESX1 · HHEX ·
HLX · Homeobox ( A1, A2,
A3, A4, A5, A7, A9, A10, A11, A13,
B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13,
D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX ·
LMX ( 1A, 1B) · MEIS ( 1, 2) ·
MEOX2 · MNX1 ·
MSX ( 1, 2) · NANOG · NKX ( 2-1, 2-2, 2-3, 2-5,
3-1, 3-2) · PBX ( 1, 2, 3) · PHF ( 1, 3, 6, 8, 10, 16, 17, 20, 21A) · PITX ( 1, 2, 3) · POU domain ( PIT-1,
BRN-3: A, B, C, Octamer transcription
factor: 1, 2, 3/4, 6, 7, 11) · OTX ( 1, 2) · PDX1 · ZEB ( 1, 2)
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(3.2) Paired box
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E2F
( 1, 2, 3, 4, 5) ·
FOX proteins ( C1, C2, D3, E1, G1, H1, K2, L2, M1, N3, O1, O3, O4, P1, P2, P3)
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(3.5) Tryptophan
clusters
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ELF ( 2, 4, 5) · EGF · ELK ( 1, 3, 4) · ERF · ERG · ETS ( 1, 2, SPIB) · ETV ( 1, 4, 5, 6) ·
FLI1 · Interferon regulatory
factors ( 1, 2, 3, 4, 5, 6, 7, 8) ·
MYB · MYBL2
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(3.6) TEA domain
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transcriptional enhancer
factor ( 1, 2, 3, 4)
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(4) β-Scaffold factors
with minor groove contacts |
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(4.3) p53
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HMGB ( 1, 2, 3) · HNF ( 1A, 1B) ·
LEF1 · SOX ( 1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY ·
SSRP1 · TCF ( 3, 4) ·
TOX ( 1, 2, 3, 4)
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(4.10) Cold-shock
domain
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(4.11) Runt
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(0) Other transcription
factors |
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(0.2) HMGI(Y)
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(0.6) Miscellaneous
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ARID ( 1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI ( 16, 35) ·
MLL ( 2, 3, T1) · MNDA ·
NFY ( A, B, C) · Rho/ Sigma
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