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nuclear receptor subfamily 1, group D, member 1
Symbol NR1D1
Alt. symbols ear-1, hRev, Rev-ErbAalpha, THRA1
Entrez 9572
HUGO 7962
OMIM 602408
RefSeq NM_021724
UniProt P20393
Other data
Locus Chr. 17 q11.2
nuclear receptor subfamily 1, group D, member 2
Symbol NR1D2
Alt. symbols BD73, RVR, EAR-1r, HZF2, Hs.37288
Entrez 9975
HUGO 7963
OMIM 602304
RefSeq XM_001130839
UniProt Q14995
Other data
Locus Chr. 3 p24.1

The Rev-ErbA proteins are members of the nuclear receptor family of intracellular transcription factors. There are two forms of the receptor, alpha and beta, each encoded by a separate gene (NR1D1 and NR1D2 respectively).[1][2]

The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor (TR) gene.[1]

The rev-Erb-α protein is a key regulatory component of the circadian clock.[3][4] In addition, rev-Erb-α appears also to regulate the break down of cartilage.[5]


  1. ^ a b Lazar MA, Jones KE, Chin WW (1990). "Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone". DNA Cell Biol. 9 (2): 77–83. doi:10.1089/dna.1990.9.77. PMID 1971514.  
  2. ^ Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD (1994). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb". Mol. Endocrinol. 8 (8): 996–1005. doi:10.1210/me.8.8.996. PMID 7997240.  
  3. ^ Yin L, Wang J, Klein PS, Lazar MA (2006). "Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock". Science 311 (5763): 1002–5. doi:10.1126/science.1121613. PMID 16484495.  
  4. ^ Wang J, Yin L, Lazar MA (2006). "The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1". J. Biol. Chem. 281 (45): 33842–8. doi:10.1074/jbc.M607873200. PMID 16968709.  
  5. ^ Chaturvedi P, Pratta M, Steplewski K, Connor J, Kumar S (2006). "Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis". Arthritis Rheum. 54 (11): 3513–22. doi:10.1002/art.22170. PMID 17075855.  

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