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Reverse tolerance or sensitization is the phenomenon of a reversal of the side-effects from a drug, or the reduction of insensitivity caused after drug tolerance has been established, or in some cases an additional increase of effects with continued use of a single drug existing alongside or not to a tolerance for other aspects of the same substance..[1][2] Typically this involves the use of an additional medication, or abstinence from a drug for a period of time, known as a drug holiday. Such drugs include amphetamines, or SSRIs.[3][4] As a result, regular users commonly experience a quick decrease of unwanted side effects, without an equivalent loss of its stimulant properties. Notably, the sensitization is induced more quickly, and persists far longer than withdrawal-related effects, suggesting a phenomenon more complex than a simple tolerance-induced withdrawal syndrome..

See also

References

  1. ^ Cross reverse tolerance between amphetamine, cocaine and morphine.
  2. ^ Drugs & Death: Profiles of illegal drug abuse. Joseph C. Rupp, M.D., Ph.D.
  3. ^ Leith N, Kuczenski R (1981). "Chronic amphetamine: tolerance and reverse tolerance reflect different behavioral actions of the drug.". Pharmacol Biochem Behav 15 (3): 399–404. doi:10.1016/0091-3057(81)90269-0. PMID 7291243.  
  4. ^ Chaudhry I, Turkanis S, Karler R (1988). "Characteristics of "reverse tolerance" to amphetamine-induced locomotor stimulation in mice.". Neuropharmacology 27 (8): 777–81. doi:10.1016/0028-3908(88)90091-3. PMID 3216957.  







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