The Full Wiki

More info on Reverse tolerance

Reverse tolerance: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Reverse tolerance or sensitization is the phenomenon of a reversal of the side-effects from a drug, or the reduction of insensitivity caused after drug tolerance has been established, or in some cases an additional increase of effects with continued use of a single drug existing alongside or not to a tolerance for other aspects of the same substance..[1][2] Typically this involves the use of an additional medication, or abstinence from a drug for a period of time, known as a drug holiday. Such drugs include amphetamines, or SSRIs.[3][4] As a result, regular users commonly experience a quick decrease of unwanted side effects, without an equivalent loss of its stimulant properties. Notably, the sensitization is induced more quickly, and persists far longer than withdrawal-related effects, suggesting a phenomenon more complex than a simple tolerance-induced withdrawal syndrome..

See also


  1. ^ Cross reverse tolerance between amphetamine, cocaine and morphine.
  2. ^ Drugs & Death: Profiles of illegal drug abuse. Joseph C. Rupp, M.D., Ph.D.
  3. ^ Leith N, Kuczenski R (1981). "Chronic amphetamine: tolerance and reverse tolerance reflect different behavioral actions of the drug.". Pharmacol Biochem Behav 15 (3): 399–404. doi:10.1016/0091-3057(81)90269-0. PMID 7291243.  
  4. ^ Chaudhry I, Turkanis S, Karler R (1988). "Characteristics of "reverse tolerance" to amphetamine-induced locomotor stimulation in mice.". Neuropharmacology 27 (8): 777–81. doi:10.1016/0028-3908(88)90091-3. PMID 3216957.  

Got something to say? Make a comment.
Your name
Your email address