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Rhynchophylline: Wikis


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Systematic (IUPAC) name
methyl (7β,16E,20α)-16-(methoxymethylene)- 2-oxocorynoxan- 17-oate
CAS number 76-66-4
ATC code none
PubChem 3033948
Chemical data
Formula C 22H28N2O4  
Mol. mass 384.46872 g/mol
SMILES eMolecules & PubChem
Synonyms methyl (E)-2-[(3R,6'R,7'S,8'aS)- 6'-ethyl- 2-oxospiro[1H-indole-3,1'- 3,5,6,7,8,8a-hexahydro- 2H-indolizine]- 7'-yl]- 3-methoxyprop- 2-enoate
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Rhynchophylline is an alkaloid found in certain Uncaria species, notably Uncaria rhynchophylla[1] and Uncaria tomentosa.[2] It is a non-competitive NMDA antagonist and calcium channel blocker[3][4]


  1. ^ Shi JS, Yu JX, Chen XP, Xu RX. Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline. Acta Pharmacologica Sinica. 2003 Feb;24(2):97-101. PMID 12546715
  2. ^ Mohamed AF, Matsumoto K, Tabata K, Takayama H, Kitajima M, Watanabe H. Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test. Journal of Pharmacy and Pharmacology. 2000 Dec;52(12):1553-61. PMID 11197086
  3. ^ Kang TH, Murakami Y, Matsumoto K, Takayama H, Kitajima M, Aimi N, Watanabe H.Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2002 Nov 22;455(1):27-34.
  4. ^ Kang TH, Murakami Y, Takayama H, Kitajima M, Aimi N, Watanabe H, Matsumoto K. Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action. Life Sci. 2004 Dec 3;76(3):331-43.


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