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Ribonucleotide reductase inhibitor: Wikis


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From Wikipedia, the free encyclopedia

Ribonucleotide reductase inhibitors are a family of anti-cancer drugs that interfere with the growth of tumor cells by blocking the formation of deoxyribonucleotides (building blocks of DNA).

Examples include:

See also


  1. ^ Zahedi Avval F, Berndt C, Pramanik A, Holmgren A (January 2009). "Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd)". Biochem. Biophys. Res. Commun.. doi:10.1016/j.bbrc.2008.12.128. PMID 19121624.  
  2. ^ Mayhew CN, Phillips JD, Cibull ML, Elford HL, Gallicchio VS (September 2002). "Short-term treatment with novel ribonucleotide reductase inhibitors Trimidox and Didox reverses late-stage murine retrovirus-induced lymphoproliferative disease with less bone marrow toxicity than hydroxyurea". Antivir. Chem. Chemother. 13 (5): 305–14. PMID 12630679.  
  3. ^ Tsimberidou AM, Alvarado Y, Giles FJ (August 2002). "Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies". Expert Rev Anticancer Ther 2 (4): 437–48. doi:10.1586/14737140.2.4.437. PMID 12647987.  
  4. ^ Bernstein LR (1998). "Mechanisms of therapeutic activity for gallium". Pharmacol. Rev. 50: 665–682.  

External links

PD-icon.svg This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".



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