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Riedel's thyroiditis
Classification and external resources
ICD-10 E06.5
ICD-9 245.3
DiseasesDB 11590
eMedicine med/2036

Riedel's thyroiditis, also called Riedel's struma is a chronic form of thyroiditis.

It is believed to be a form of autoimmune thyroiditis.[1]

Contents

Pathophysiology

Riedel's thyroiditis is characterized by a replacement of the normal thyroid parenchyma by a dense fibrosis that invades adjacent structures of the neck and extends beyond the thyroid capsule.[2] This makes the thyroid gland stone-hard and fixed to adjacent structures. The inflammatory process infiltrates muscles and causes symptoms of tracheal compression. Surgical treatment is required to relieve tracheal or esophageal obstruction.

A shared mechanism with retroperitoneal fibrosis and sclerosing cholangitis has been suggested.[3]

Prevalence

Riedel's thyroiditis is classified as rare. Most patients remain euthyroid, but approximately 30% of patients become hypothyroid and very few patients are hyperthyroid. It is most seen in women.[4]

Treatment

Tamoxifen has been proposed as part of a treatment plan.[5]

Eponym

It is named for Bernhard Riedel. He first recognized the disease In 1883 and published its description in 1896.[6][7]

References

  1. ^ autoimmune thyroiditis at Dorland's Medical Dictionary
  2. ^ Cho MH, Kim CS, Park JS, et al. (August 2007). "Riedel's thyroiditis in a patient with recurrent subacute thyroiditis: a case report and review of the literature" ( – Scholar search). Endocr. J. 54 (4): 559–62. doi:10.1507/endocrj.K06-186. PMID 17603227. http://joi.jlc.jst.go.jp/JST.JSTAGE/endocrj/K06-186?from=PubMed.  
  3. ^ De Boer WA (May 1993). "Riedel's thyroiditis, retroperitoneal fibrosis, and sclerosing cholangitis: diseases with one pathogenesis?". Gut 34 (5): 714. doi:10.1136/gut.34.5.714. PMID 8504980. PMC 1374200. http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=8504980.  
  4. ^ eMedicine
  5. ^ Dabelic N, Jukic T, Labar Z, Novosel SA, Matesa N, Kusic Z (April 2003). "Riedel's thyroiditis treated with tamoxifen" (PDF). Croat. Med. J. 44 (2): 239–41. PMID 12698518. http://www.cmj.hr/2003/44/2/12698518.pdf.  
  6. ^ B. M. C. L. Riedel. Die chronische, zur Bildung eisenharter Tumoren führende Entzündung der Schilddrüse. Verhandlungen der deutschen Gesellschaft für Chirurgie, 1896, 25: 101-105.
  7. ^ synd/3242 at Who Named It?
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