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Rifapentine: Wikis

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Rifapentine
Systematic (IUPAC) name
(7S,9E,11S,12R,13 S,14R,15R,16R,17S,18S,19 E,21Z,26E)-26-{[(4-cyclopentylpiperazin-1-yl)amino]methylidene}-2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27-trioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1 4,7.05,28]triaconta-1(28),2,4,9,19,21,25(29)-heptaen-13-yl acetate
Identifiers
CAS number 61379-65-5
ATC code J04AB05
PubChem 5462354
DrugBank APRD01217
Chemical data
Formula C 47H64N4O12  
Mol. mass 877.031 g/mol
Synonyms 3{[(4-cyclopentyl-1-piperazinyl)imino]methyl}rifamycin
Pharmacokinetic data
Bioavailability increases when administered with food
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Rifapentine (INN, marketed under the brand name Priftin by Sanofi-Aventis) is an antibiotic drug used in the treatment of tuberculosis.

History

Rifapentine was first synthesized in 1965 by the same company that produced rifampin. The drug was approved by the Food and Drug Administration (FDA) in June 1998.

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