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Ritanserin: Wikis

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Ritanserin
Systematic (IUPAC) name
6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[2,3-b]pyrimidin-5-one
Identifiers
CAS number 87051-43-2
ATC code none
PubChem 5074
Chemical data
Formula C 27H25F2N3OS 
Mol. mass 477.569 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Ritanserin is a serotonin antagonist with wide-reaching possibilities for the treatment of many neurological disorders.

When used together with typical antipsychotics in the treatment of schizophrenia is able to decrease negative symptoms and adds some "atypicality" as parkinsonism is slightly decreased.

Possible effects on platelets have also been proposed.[1]

Pharmacology

Ritanserin is a 5-HT2 receptor antagonist[2] (Ki = 0.39 nM). It has anxiolytic effects in vivo.

References

  1. ^ Wagner B, Schneider B, Blöchl-Daum B, et al. (October 1990). "Effect of ritanserin, a 5-hydroxytryptamine2-receptor antagonist, on platelet function and thrombin generation at the site of plug formation in vivo". Clinical pharmacology and therapeutics 48 (4): 419–23. PMID 2146058.  
  2. ^ Akhondzadeh S, Malek-Hosseini M, Ghoreishi A, Raznahan M, Rezazadeh SA (September 2008). "Effect of ritanserin, a 5HT2A/2C antagonist, on negative symptoms of schizophrenia: A double-blind randomized placebo-controlled study". Progress in neuro-psychopharmacology & biological psychiatry. doi:10.1016/j.pnpbp.2008.08.020. PMID 18801405. http://linkinghub.elsevier.com/retrieve/pii/S0278-5846(08)00258-3.  
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