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Ritodrine: Wikis


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Systematic (IUPAC) name
CAS number 26652-09-5
ATC code G02CA01
PubChem 33572
DrugBank APRD00541
Chemical data
Formula C17H21NO3 
Mol. mass 287.354 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Protein binding ~56%
Half life 1.7-2.6 hours
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral, parenteral

Ritodrine hydrochloride (trade name Yutopar) is a tocolytic drug, used to stop premature labor.[1] It is available in oral tablets or as an injection.


Ritodrine is a Beta-2 adrenergic receptor agonist - a class of medication used for smooth muscle relaxation (other types are used in asthma or other pulmonary diseases like salbutamol)

Side effects and potential contraindications

Most side effects of beta-2 agonists result from their concurrent beta-1 activity, and include increase in heart rate, rise in systolic pressure, decrease in diastolic pressure, chest pain secondary to MI, and arrhythmia. Beta agonists may also cause fluid retention secondary to decrease in water clearance, which when added to the tachycardia and increased myocardial work, may result in cardiac failure. In addition, they increase gluconeogenesis in the liver and muscle resulting in hyperglycemia, which increases insulin requirements in diabetic patients. The passage of beta-agonists through the placenta does occur and may be responsible for fetal tachycardia, as well as hypoglycemia or hyperglycemia at birth.

Patients with Type 2 Diabetes, high blood pressure or migraines should bring this to their doctor's attention before receiving care.

It has also been associated with post-partum hemorrhage.


  1. ^ Li X, Zhang Y, Shi Z (February 2005). "Ritodrine in the treatment of preterm labour: a meta-analysis". The Indian journal of medical research 121 (2): 120–7. PMID 15756046. 


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