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Ro48-8684
Systematic (IUPAC) name
3-(5-dipropylaminomethyloxazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one
Identifiers
CAS number  ?
ATC code  ?
PubChem 9866317
Chemical data
Formula C 22H26FN5O2  
Mol. mass 411.472
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Ro48-8684 is a water-soluble benzodiazepine derivative developed by Hoffman-LaRoche in the 1990s, which was designed along with Ro48-6791 as an improved replacement for midazolam, but ultimately proved to have little advantages over the parent drug and has not been introduced into clinical practice.[1][2]

See also

References

  1. ^ van Gerven JM, Roncari G, Schoemaker RC, Massarella J, Keesmaat P, Kooyman H, Heizmann P, Zell M, Cohen AF, Dingemanse J. Integrated pharmacokinetics and pharmacodynamics of Ro 48-8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects. British Journal of Clinical Pharmacology. 1997 Nov;44(5):487-93. PMID 9384466
  2. ^ Albrecht S, Hering W, Ihmsen H, Schwilden H, Schüttler J. Pharmacokinetic-pharmacodynamic modeling in phase II of drug development. A comparative study with young and old volunteers with benzdiazepine as an example. (German) Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie. 1999 Oct;34(10):634-7. PMID 10548960
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