The Full Wiki

More info on Ro 04-6790

Ro 04-6790: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


(Redirected to Ro04-6790 article)

From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
CAS number 202466-68-0
ATC code  ?
PubChem 5312145
Chemical data
Formula C 12H16N6O2S 
Mol. mass 308.359 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Ro04-6790 is a drug developed by Hoffmann–La Roche, which has applications in scientific research. It acts as a potent and selective receptor antagonist for the 5-HT6 serotonin receptor subtype, with little or no affinity at other receptors. In common with other drugs of this class,[1] Ro04-6790 has nootropic effects in animals,[2] and reduces the amnesia produced by amnestic drugs such as dizocilpine[3] and scopolamine.[4]


  1. ^ Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008 Nov;55(6):1015-22. PMID 18655798
  2. ^ King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC. Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task. Psychopharmacology (Berlin). 2008 Oct 7. PMID 18839151
  3. ^ Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N. The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801. Behavioural Brain Research. 2008 Apr 9;188(2):304-9. PMID 18164078
  4. ^ Woolley ML, Marsden CA, Sleight AJ, Fone KC. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology (Berlin). 2003 Dec;170(4):358-67. PMID 13680084


Got something to say? Make a comment.
Your name
Your email address