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Robalzotan
Systematic (IUPAC) name
(3R)-3-[di(cyclobutyl)amino]-8-fluoro-3,4-dihydro-2H-chromene-5-carboxamide
Identifiers
CAS number 169758-66-1
ATC code none
PubChem 3055171
Chemical data
Formula C 18H23FN2O2  
Mol. mass 318.174 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Robalzotan (NAD-299) is a drug which acts as a selective antagonist at the 5-HT1A receptor.[1] It was shown to completely reverse the temporary autoreceptor-mediated inhibitory effect on serotonin release caused by the acute administration of selective serotonin reuptake inhibitors (SSRIs) such as citalopram and paroxetine.[2] It is subsequently being investigated by AstraZeneca as a potential antidepressant.[3]

References

  1. ^ Jerning E, Svantesson GT, Mohell N. (1998). "Receptor binding characteristics of [3H]NAD-299, a new selective 5-HT1A receptor antagonist.". Eur J Pharmacol. 360 (2-3): 219–225. PMID 9851589.  
  2. ^ Arborelius L, Wallsten C, Ahlenius S, Svensson TH. (1999). "The 5-HT(1A) receptor antagonist robalzotan completely reverses citalopram-induced inhibition of serotonergic cell firing.". Eur J Pharmacol. 382 (2): 133–138. PMID 10528148.  
  3. ^ Mucke HA. (2000). "Robalzotan AstraZeneca.". Curr Opin Investig Drugs. 1 (2): 236–240. PMID 11249580.  







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