The Full Wiki

More info on Rocuronium

Rocuronium: Wikis

  
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Rocuronium
Systematic (IUPAC) name
(2β,3α,5α,16β,17β)-17-(acetyloxy)-16-(1-allylpyrrolidinium-1-yl)-3-hydroxy-2-morpholin-4-ylandrostane
Identifiers
CAS number 119302-91-9
ATC code M03AC09
PubChem 441290
DrugBank APRD01221
Chemical data
Formula C 32H53N2O4 +
Mol. mass 529.774 g/mol
Synonyms [3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1 H-cyclopenta[a]phenanthren-17-yl] acetate
Pharmacokinetic data
Bioavailability NA
Protein binding ~30%
Metabolism some de-acetylation
Half life 66–80 minutes
Excretion Unchanged, in bile and urine
Therapeutic considerations
Pregnancy cat.  ?
Legal status POM (UK)
Routes Intravenous
 Yes check.svgY(what is this?)  (verify)

Rocuronium (Zemuron, Esmeron) is an aminosteroid non-depolarizing (that is, it does not cause initial stimulation of muscles before weakening them) neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action.[1] It is marketed under the trade name of Zemuron in the United States and Esmeron in most other countries.

There is considered to be some risk of allergic reaction to the drug in occasional patients (particularly those with asthma), but a similar incidence of allergic reactions has been observed by using other members of the same drug class (non-depolarizing neuromuscular blocking drugs).[2] The drug is commonly used in modern anaesthesia.

The γ-cyclodextrin derivative sugammadex has been recently introduced as a novel agent to reverse the action of rocuronium.[3]

References

  1. ^ Hunter JM (April 1996). "Rocuronium: the newest aminosteroid neuromuscular blocking drug". British Journal of Anaesthesia 76 (4): 481–3. PMID 8652315. http://bja.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=8652315.  
  2. ^ Burburan SM, Xisto DG, Rocco PR (June 2007). "Anaesthetic management in asthma". Minerva Anestesiologica 73 (6): 357–65. PMID 17115010.  
  3. ^ Naguib M (March 2007). "Sugammadex: another milestone in clinical neuromuscular pharmacology". Anesthesia and Analgesia 104 (3): 575–81. doi:10.1213/01.ane.0000244594.63318.fc. PMID 17312211. http://www.anesthesia-analgesia.org/cgi/pmidlookup?view=long&pmid=17312211.  







Got something to say? Make a comment.
Your name
Your email address
Message