Route 22 is a bus route operated by the Maryland Transit Administration in Baltimore. The line currently operates between the Mondawmin Metro Subway Station and Bayview Medical Center, serving Television Hill, the Woodberry Light Rail Stop), Hampden, The Rotunda, Homewood, Johns Hopkins University, Waverly, Belair-Edison, and Highlandtown.
Part of the route is the successor to the No. 34 streetcar and bus line.
In 1907, the no. 34 streetcar started operating, known then as the Highlandtown Short Line. It operated until 1950, when it was converted in a bus route.
Route 22 started operating in 1947 as the successor to Bus Route S, which operated along a similar route starting in 1937.
In 1971, selected trips were extended through Southwest Baltimore along a route similar to today's Route 16. This service operated to Brooklyn, serving Rosemont, Lutheran Hospital, and the corridor of Hilton Street, Caton Avenue, and Patapsco Avenue.
In 1975, Route 22 was modified to absorb parts of Routes 34 and 57.
In January 2001, service between Mondawmin and Brooklyn was split into a separate line identified as Route 16 in order to simplify an improve the reliability of service. The frequency of Route 16 would be increased later during the decade.
In 2006, as part of the Greater Baltimore Bus Initiative, the frequency of service on Route 22 was nearly doubled at most times to provide improved crosstown service, though the route of the line was not changed.
In the novel The Reappearance of Sam Webber By Jonathon Scott Fuqua, the narrator describes throughout the book catching the bus (not identified in the book as no. 22) to various points along Route 22.
Part of the route of Route 22 is described in Journeys to the heart of Baltimore By Michael Olesker, in reference to where various ethnic groups board and depart, though the number 22 is not mentioned.