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Ruthenium red: Wikis

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Ammoniated ruthenium oxychloride
Ruthenium red cation.svg
Identifiers
CAS number 11103-72-3
Properties
Molecular formula H42Cl6N14O2Ru3
Molar mass 786.36 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Ruthenium red is a Ruthenium containing red staining dye. The organic Ruthenium Red is polycationic cell biology reagent that tightly binds to tubulin dimers and Ryanodine receptor. It is a potent inhibitor of intracellular calcium release by Ryanodine receptors at nanomolar concentrations (km ~20 nM). [1]

The inorganic dye ammoniated ruthenium oxychloride used in histology to stain aldehyde fixed mucopolysaccharides, is sometimes also called Ruthenium red, and inhibits calcium transport through membrane channels.

Ruthenium red also inhibits the calcium uptake by isolated mitochondria. [2]

References

  1. ^ TRIPATHY, LE XU ASHUTOSH, PASEK, DANIEL A., MEISSNER, GERHARD Potential for Pharmacology of Ryanodine Receptor/Calcium Release Channels Ann NY Acad Sci 1998 853: 130-148 [1]
  2. ^ Hajnóczky G, Csordás G, Das S, Garcia-Perez C, Saotome M, Sinha Roy S, Yi M. Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis. Cell Calcium 2006;40(5-6):553-60

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