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sphingosine-1-phosphate receptor 1
Identifiers
Symbols S1PR1; S1P1; EDG1; ECGF1; CHEDG1; D1S3362; EDG-1
External IDs OMIM601974 MGI1096355 HomoloGene1071 IUPHAR: S1P1 GeneCards: S1PR1 Gene
RNA expression pattern
PBB GE EDG1 204642 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1901 13609
Ensembl ENSG00000170989 ENSMUSG00000045092
UniProt P21453 Q3UUK3
RefSeq (mRNA) NM_001400 XM_986946
RefSeq (protein) NP_001391 XP_992040
Location (UCSC) Chr 1:
101.48 - 101.48 Mb
Chr 3:
115.7 - 115.71 Mb
PubMed search [1] [2]

S1PR1 (sphingosine-1-phosphate receptor 1) also known as S1P1 and EDG1 (endothelial differentiation gene 1) is a protein which in humans is encoded by the S1PR1 gene. S1PR1 encodes a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

Contents

Function

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.[1]

See also

Interactions

S1PR1 has been shown to interact with 5-HT1A receptor,[2] GNAI1[3] and GNAI3.[3]

References

  1. ^ "Entrez Gene: EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1901.  
  2. ^ Salim, Kamran; Fenton Tim, Bacha Jamil, Urien-Rodriguez Hector, Bonnert Tim, Skynner Heather A, Watts Emma, Kerby Julie, Heald Anne, Beer Margaret, McAllister George, Guest Paul C (May. 2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. (United States) 277 (18): 15482–5. doi:10.1074/jbc.M201539200. ISSN 0021-9258. PMID 11854302.  
  3. ^ a b Lee, M J; Evans M, Hla T (May. 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. (UNITED STATES) 271 (19): 11272–9. ISSN 0021-9258. PMID 8626678.  

Further reading

  • Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441.  
  • Igarashi Y (2002). "[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 476–9. PMID 11915345.  
  • Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348.  
  • Takuwa Y, Takuwa N, Sugimoto N (2003). "The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.". J. Biochem. 131 (6): 767–71. PMID 12038970.  
  • Hla T, Maciag T (1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.". J. Biol. Chem. 265 (16): 9308–13. PMID 2160972.  
  • Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.". J. Biol. Chem. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • An S, Bleu T, Huang W, et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.". FEBS Lett. 417 (3): 279–82. doi:10.1016/S0014-5793(97)01301-X. PMID 9409733.  
  • Lee MJ, Van Brocklyn JR, Thangada S, et al. (1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.". Science 279 (5356): 1552–5. doi:10.1126/science.279.5356.1552. PMID 9488656.  
  • Lee MJ, Thangada S, Liu CH, et al. (1998). "Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.". J. Biol. Chem. 273 (34): 22105–12. doi:10.1074/jbc.273.34.22105. PMID 9705355.  
  • Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.  
  • Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.  
  • Lee MJ, Thangada S, Claffey KP, et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.". Cell 99 (3): 301–12. doi:10.1016/S0092-8674(00)81661-X. PMID 10555146.  
  • Igarashi J, Michel T (2000). "Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.". J. Biol. Chem. 275 (41): 32363–70. doi:10.1074/jbc.M003075200. PMID 10921915.  
  • Parrill AL, Wang D, Bautista DL, et al. (2001). "Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.". J. Biol. Chem. 275 (50): 39379–84. doi:10.1074/jbc.M007680200. PMID 10982820.  
  • Liu Y, Wada R, Yamashita T, et al. (2000). "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.". J. Clin. Invest. 106 (8): 951–61. doi:10.1172/JCI10905. PMID 11032855.  
  • Murphy WJ, Eizirik E, Johnson WE, et al. (2001). "Molecular phylogenetics and the origins of placental mammals.". Nature 409 (6820): 614–8. doi:10.1038/35054550. PMID 11214319.  
  • Hobson JP, Rosenfeldt HM, Barak LS, et al. (2001). "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.". Science 291 (5509): 1800–3. doi:10.1126/science.1057559. PMID 11230698.  
  • Lee MJ, Thangada S, Paik JH, et al. (2001). "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.". Mol. Cell 8 (3): 693–704. doi:10.1016/S1097-2765(01)00324-0. PMID 11583630.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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