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sphingosine-1-phosphate receptor 1
Symbols S1PR1; S1P1; EDG1; ECGF1; CHEDG1; D1S3362; EDG-1
External IDs OMIM601974 MGI1096355 HomoloGene1071 IUPHAR: S1P1 GeneCards: S1PR1 Gene
RNA expression pattern
PBB GE EDG1 204642 at tn.png
More reference expression data
Species Human Mouse
Entrez 1901 13609
Ensembl ENSG00000170989 ENSMUSG00000045092
UniProt P21453 Q3UUK3
RefSeq (mRNA) NM_001400 XM_986946
RefSeq (protein) NP_001391 XP_992040
Location (UCSC) Chr 1:
101.48 - 101.48 Mb
Chr 3:
115.7 - 115.71 Mb
PubMed search [1] [2]

S1PR1 (sphingosine-1-phosphate receptor 1) also known as S1P1 and EDG1 (endothelial differentiation gene 1) is a protein which in humans is encoded by the S1PR1 gene. S1PR1 encodes a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).



The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.[1]

See also


S1PR1 has been shown to interact with 5-HT1A receptor,[2] GNAI1[3] and GNAI3.[3]


  1. ^ "Entrez Gene: EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1".  
  2. ^ Salim, Kamran; Fenton Tim, Bacha Jamil, Urien-Rodriguez Hector, Bonnert Tim, Skynner Heather A, Watts Emma, Kerby Julie, Heald Anne, Beer Margaret, McAllister George, Guest Paul C (May. 2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. (United States) 277 (18): 15482–5. doi:10.1074/jbc.M201539200. ISSN 0021-9258. PMID 11854302.  
  3. ^ a b Lee, M J; Evans M, Hla T (May. 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. (UNITED STATES) 271 (19): 11272–9. ISSN 0021-9258. PMID 8626678.  

Further reading

  • Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441.  
  • Igarashi Y (2002). "[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 476–9. PMID 11915345.  
  • Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348.  
  • Takuwa Y, Takuwa N, Sugimoto N (2003). "The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.". J. Biochem. 131 (6): 767–71. PMID 12038970.  
  • Hla T, Maciag T (1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.". J. Biol. Chem. 265 (16): 9308–13. PMID 2160972.  
  • Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.". J. Biol. Chem. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • An S, Bleu T, Huang W, et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.". FEBS Lett. 417 (3): 279–82. doi:10.1016/S0014-5793(97)01301-X. PMID 9409733.  
  • Lee MJ, Van Brocklyn JR, Thangada S, et al. (1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.". Science 279 (5356): 1552–5. doi:10.1126/science.279.5356.1552. PMID 9488656.  
  • Lee MJ, Thangada S, Liu CH, et al. (1998). "Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.". J. Biol. Chem. 273 (34): 22105–12. doi:10.1074/jbc.273.34.22105. PMID 9705355.  
  • Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.  
  • Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.  
  • Lee MJ, Thangada S, Claffey KP, et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.". Cell 99 (3): 301–12. doi:10.1016/S0092-8674(00)81661-X. PMID 10555146.  
  • Igarashi J, Michel T (2000). "Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.". J. Biol. Chem. 275 (41): 32363–70. doi:10.1074/jbc.M003075200. PMID 10921915.  
  • Parrill AL, Wang D, Bautista DL, et al. (2001). "Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.". J. Biol. Chem. 275 (50): 39379–84. doi:10.1074/jbc.M007680200. PMID 10982820.  
  • Liu Y, Wada R, Yamashita T, et al. (2000). "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.". J. Clin. Invest. 106 (8): 951–61. doi:10.1172/JCI10905. PMID 11032855.  
  • Murphy WJ, Eizirik E, Johnson WE, et al. (2001). "Molecular phylogenetics and the origins of placental mammals.". Nature 409 (6820): 614–8. doi:10.1038/35054550. PMID 11214319.  
  • Hobson JP, Rosenfeldt HM, Barak LS, et al. (2001). "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.". Science 291 (5509): 1800–3. doi:10.1126/science.1057559. PMID 11230698.  
  • Lee MJ, Thangada S, Paik JH, et al. (2001). "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.". Mol. Cell 8 (3): 693–704. doi:10.1016/S1097-2765(01)00324-0. PMID 11583630.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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