The Full Wiki

More info on S1PR5

S1PR5: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Sphingosine-1-phosphate receptor 5
Symbols S1PR5; EDG8; S1P5; S1PR5; SPPR-1; SPPR-2
External IDs OMIM605146 MGI2150641 HomoloGene11031 IUPHAR: S1P5 GeneCards: S1PR5 Gene
RNA expression pattern
PBB GE EDG8 221417 x at tn.png
More reference expression data
Species Human Mouse
Entrez 53637 94226
Ensembl ENSG00000180739 ENSMUSG00000045087
UniProt Q9H228 Q91X56
RefSeq (mRNA) NM_030760 NM_053190
RefSeq (protein) NP_110387 NP_444420
Location (UCSC) Chr 19:
10.48 - 10.49 Mb
Chr 9:
20.99 - 21 Mb
PubMed search [1] [2]

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.[1]


See also


Further reading

  • Im DS, Heise CE, Ancellin N, et al. (2000). "Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.". J. Biol. Chem. 275 (19): 14281–6. doi:10.1074/jbc.275.19.14281. PMID 10799507.  
  • Malek RL, Toman RE, Edsall LC, et al. (2001). "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.". J. Biol. Chem. 276 (8): 5692–9. doi:10.1074/jbc.M003964200. PMID 11069896.  
  • Hla T. Sphingosine 1-phosphate receptors.. 64. pp. 135–142. PMID 11331101.  
  • Im DS, Clemens J, Macdonald TL, Lynch KR (2001). "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.". Biochemistry 40 (46): 14053–60. doi:10.1021/bi011606i. PMID 11705398.  
  • Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.  
  • Niedernberg A, Scherer CR, Busch AE, Kostenis E (2002). "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists.". Biochem. Pharmacol. 64 (8): 1243–50. doi:10.1016/S0006-2952(02)01289-3. PMID 12234605.  
  • Kothapalli R, Kusmartseva I, Loughran TP (2003). "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia.". Biochim. Biophys. Acta 1579 (2-3): 117–23. PMID 12427546.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ulfig N, Briese M (2005). "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers.". Acta Histochem. 106 (5): 373–8. doi:10.1016/j.acthis.2004.08.002. PMID 15530552.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address