The Full Wiki

More info on SB-649915

SB-649915: Wikis

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


(Redirected to SB-649,915 article)

From Wikipedia, the free encyclopedia

Systematic (IUPAC) name
CAS number  ?
ATC code  ?
PubChem 10225553
Chemical data
Formula C 26H29N3O3  
Mol. mass 431.526 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

SB-649,915 is a psychoactive drug and research chemical that is being investigated for its antidepressant and anxiolytic properties.[1] It acts as a serotonin reuptake inhibitor, 5-HT1A receptor antagonist, and 5-HT1B receptor antagonist. In contrast to other current antidepressants such as the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a fast onset of action and may also likely have greater efficacy than the SSRIs. This is likely due to blockade of 5-HT1A autoreceptors which inhibit serotonin release.


  1. ^ Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS. (2007). "SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.". Neuropsychopharmacology. 32 (10): 2163–2172. PMID 17356576.  

Got something to say? Make a comment.
Your name
Your email address