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SB 203580: Wikis


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SB 203580[1]
SB 203580.png
IUPAC name
Other names RWJ-64809;
CAS number 152121-47-6
PubChem 176155
Molecular formula C21H16FN3OS
Molar mass 377.43 g/mol
Appearance White to off-white solid
Solubility in DMSO 50 mg/mL
R-phrases R22 R41
S-phrases S26 S39
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

SB 203580 is an inhibitor of MAP kinase reactivating kinase.[2] It suppresses the activation of MAPKAP kinase-2 and inhibits the phosphorylation of heat shock protein 27.


  1. ^ SB 203580 at Sigma-Aldrich
  2. ^ Cuenda, Ana; Rouse, John; Doza, Yair N.; Meier, Roger; Cohen, Philip; Gallagher, Timothy F.; Young, Peter R.; Lee, John C. (1995). "SB 203580 is a specific inhibitor of a MAP kinase homolog which is stimulated by cellular stresses and interleukin-1". FEBS Letters 364 (2): 229–33. doi:10.1016/0014-5793(95)00357-F.  


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