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SCGB2A2: Wikis

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secretoglobin, family 2A, member 2
Identifiers
Symbol TAS2R16
Entrez 42502
HUGO 70501
OMIM 604867
UniProt Q132963
Other data
Locus Chr. 11 q12.3-q13.1

SCGB2A2 is a gene located on chromosome 11, at locus 11q13. It codes a protein named « secretoglobin, family 2A, member 2 », according to the official international nomenclature. Other names for the protein are : mammaglobin (MGB, MAM)[1], mammaglobin-1 (MGB1), precursor of mammaglobin-A (MGBA), uteroglobin 2 (UGB2). SCGB2A2 is member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seems to be involved in cell signalling, immune response, chemotaxis, and could also serve as transporters for steroid hormones in humans[2][3].

SCGB2A2 and breast cancer

SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells[4].

References

  1. ^ Watson, MA; Fleming TP. (1996). "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer". Cancer Research 56: 860 – 865. PMID 8631025.  
  2. ^ Klug, J; Beier HM, Bernard A, Chilton BS, Fleming TP, Lehrer RI, Miele L, Pattabiraman N, Singh G. (2000). "Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report". Annals of the New York Academy of Sciences 923: 348 – 354. PMID 11193777.  
  3. ^ Brown, NM; Stenzel TT, Friedman PN, Henslee J, Huper G, Marks JR. (2006). "Evaluation of expression based markers for the detection of breast cancer cells". Breast Cancer Research and Treatment 97: 41 – 47. doi:10.1007/s10549-005-9085-8. PMID 16319979.  
  4. ^ Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer 13: 1033 – 1067. doi:10.1677/ERC-06-0001. PMID 17158753.  

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