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Sodium channel, voltage-gated, type II, beta
Symbols SCN2B;
External IDs OMIM601327 MGI106921 HomoloGene3373 GeneCards: SCN2B Gene
RNA expression pattern
PBB GE SCN2B 210364 at tn.png
PBB GE SCN2B 210363 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6327 72821
Ensembl ENSG00000149575 ENSMUSG00000070304
UniProt O60939 Q1MXF8
RefSeq (mRNA) NM_004588 NM_001014761
RefSeq (protein) NP_004579 NP_001014761
Location (UCSC) Chr 11:
117.54 - 117.55 Mb
Chr 9:
44.87 - 44.88 Mb
PubMed search [1] [2]

Sodium channel subunit beta-2 is a protein that in humans is encoded by the SCN2B gene.[1][2]


See also


  1. ^ Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics 57 (2): 323-31. doi:10.1006/geno.1998.5735. PMID 10198179.  
  2. ^ "Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta".  

Further reading

  • Hartshorne RP, Catterall WA (1984). "The sodium channel from rat brain. Purification and subunit composition.". J. Biol. Chem. 259 (3): 1667–75. PMID 6319405.  
  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.  
  • Isom LL, Ragsdale DS, De Jongh KS, et al. (1996). "Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif.". Cell 83 (3): 433–42. doi:10.1016/0092-8674(95)90121-3. PMID 8521473.  
  • Eubanks J, Srinivasan J, Dinulos MB, et al. (1997). "Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel.". Neuroreport 8 (12): 2775–9. doi:10.1097/00001756-199708180-00025. PMID 9295116.  
  • Bolino A, Seri M, Caroli F, et al. (1999). "Exclusion of the SCN2B gene as candidate for CMT4B.". Eur. J. Hum. Genet. 6 (6): 629–34. doi:10.1038/sj.ejhg.5200220. PMID 9887383.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kim DY, Ingano LA, Carey BW, et al. (2005). "Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration.". J. Biol. Chem. 280 (24): 23251–61. doi:10.1074/jbc.M412938200. PMID 15833746.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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