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Sodium channel, voltage-gated, type VII, alpha
Symbols SCN7A; SCN6A; Nax
External IDs OMIM182392 MGI102965 HomoloGene55706 GeneCards: SCN7A Gene
RNA expression pattern
PBB GE SCN7A 207864 at tn.png
More reference expression data
Species Human Mouse
Entrez 6332 20272
Ensembl ENSG00000136546 ENSMUSG00000034810
UniProt Q01118 n/a
RefSeq (mRNA) NM_002976 NM_009135
RefSeq (protein) NP_002967 NP_033161
Location (UCSC) Chr 2:
166.97 - 167.05 Mb
Chr 2:
66.47 - 66.59 Mb
PubMed search [1] [2]

Sodium channel protein type 7 subunit alpha is a protein that in humans is encoded by the SCN7A gene.[1][2]


See also

Scn7a is the name of the gene that encodes to a membrane protein, in particular a Sodium Channel Nax (also known as NaG, Nav2.1, etc.) It belongs to a family of Sodium Channel known as Voltage-Gated, but is not activated by changes in the membrane's voltage, as happen usually in the members of this family (Nav1.1 to Nav1.9); it activates by changes in the extracellular concentration of sodium [~150 mM].


  1. ^ Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics 57 (2): 323-31. doi:10.1006/geno.1998.5735. PMID 10198179.  
  2. ^ "Entrez Gene: SCN7A sodium channel, voltage-gated, type VII, alpha".  

Further reading

  • Meyers KJ, Mosley TH, Fox E, et al. (2007). "Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks.". Hypertension 49 (5): 992–9. doi:10.1161/HYPERTENSIONAHA.106.081265. PMID 17339538.  
  • Zhang KX, Zhu DL, He X, et al. (2004). "[Association of single nucleotide polymorphism in human SCN7A gene with essential hypertension in Chinese]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20 (6): 463–7. PMID 14669210.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Goldin AL, Barchi RL, Caldwell JH, et al. (2001). "Nomenclature of voltage-gated sodium channels.". Neuron 28 (2): 365–8. doi:10.1016/S0896-6273(00)00116-1. PMID 11144347.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • George AL, Knops JF, Han J, et al. (1994). "Assignment of a human voltage-dependent sodium channel alpha-subunit gene (SCN6A) to 2q21-q23.". Genomics 19 (2): 395–7. doi:10.1006/geno.1994.1081. PMID 8188276.  
  • Boyle MB, Heslip LA (1995). "Voltage-dependent Na+ channel mRNA expression in pregnant myometrium.". Recept. Channels 2 (3): 249–53. PMID 7874451.  
  • Han JA, Lu CM, Brown GB, Rado TA (1991). "Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23.". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 335–9. doi:10.1073/pnas.88.2.335. PMID 1846440.  
  • George AL, Knittle TJ, Tamkun MM (1992). "Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.". Proc. Natl. Acad. Sci. U.S.A. 89 (11): 4893–7. doi:10.1073/pnas.89.11.4893. PMID 1317577.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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